ß-Nicotinamide adenine dinucleotide phosphate tetrasodium salt (NADPH-Na4, reduced form) ≥98%
Supplier: E. Becker & Co. GmbH
50 mg/ml, clear colorless to slightly yellow solution.
- White Powder
- Store at −0 °C, desiccate, protect from light, store under nitrogen
β-NADPH is a product of the pentose phosphate pathway, a multifunctional pathway whose primary purpose is to generate reducing power in the form of β -NADPH. β-NADPH transfers H+ and 2 e- to oxidized precursors in the reduction reactions of biosynthesis. Thus, β-NADPH cycles between catabolic and biosynthetic reactions and serves as the carrier of reducing power in the same way that ATP serves as the carrier of energy. β-NADPH is also involved with Cytochrome P450 electron transport systems. Enzymes using β-NADPH as a coenzyme include glutathione reductase, diacetyl reductase, dihydrofolate reductase, glutamic dehydrogenase, p-hydroxybenzoate hydroxylase, NADPH-FMN oxidoreductase, nitrate reductase and thioredoxin reductase.
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).
Electron donor; cofactor for many redox enzymes including nitric oxide synthetase.