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(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methanamine
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(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methanamine
Supplier:
AMBEED, INC
Description:
[3-(4-Chlorophenoxy)phenyl]methylamine hydrochloride 95%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 008838-5G , MDL Number: MFCD00143266
Supplier:
Thermo Scientific Chemicals
Description:
Grade: 97. Melting Point C46-48*. Boiling Point C: 113-115*/4mm. C7H8IN. 39959-59-6. CORROSIVE AIR SENSITIVE LIGHT SENSITIVE
Supplier:
Adipogen
Description:
Quizartinib (AC220) is a second-generation FLT3 inhibitor that has shown promising activity in AML in Phase II clinical trials. It inhibits mutant and wild-type FLT3 in vivo at 0.1 and 0.5µM, respectively, and has shown favorable activity and tolerability in phase I and II trials in acute myeloid leukemia, with QT prolongation as the dose-limiting toxicity. Recently, AC220 has also been shown to be an effective inhibitor of ATP-binding cassette (ABC) proteins ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein). Quizartinib inhibited transport of fluorescent ABCG2 and ABCB1 substrates in ABCG2- and ABCB1-overexpressing cells in a concentration-dependent manner, from 0.1 to 5µM and from 0.5 to 10µM, respectively, and inhibited-IAAP photolabeling of ABCG2 and ABCB1 with IC(50) values of 0.07 and 3.3µM, respectively.
Catalog Number:
(AAAL19165-03)
Supplier:
Thermo Scientific Chemicals
Description:
Grade: 97. Melting Point C. Boiling Point C: NA. C8H9F2NO. 243863-36-7. CORROSIVE AIR SENSITIVE
Catalog Number:
(AAAL11972-06)
Supplier:
Thermo Scientific Chemicals
Description:
. Grade:95, Melting Point C. Boiling Point C:74-76*/0. 1mm. C7H7Cl2N. 10541-69-2. CORROSIVE AIR SENSITIVE
Supplier:
Thermo Scientific Chemicals
Description:
2-Bromo-6-fluorobenzylamine hydrochloride, 96%
Supplier:
BeanTown Chemical
Description:
CAS: 10269-01-9; MDL No: MFCD01026119
UN No: UN2735; Haz Class: 8; Packing Group: III
Liquid; Molecular Formula: C7H8BrN; MW: 186.05
Supplier:
AAT BIOQUEST INC
Description:
Among the ratiometric calcium indicators, Fura-2 and Indo-1 are most commonly used.
Catalog Number:
(101775-824)
Supplier:
Spectrum Chemicals
Description:
Dimethylamine Hydrochloride, purity: 98 %, CAS number: 506-59-2, Molecular Formula: C2H7N.HCl, Molecular weight: 81.55, Form: Solid, synonyms: Hydrochloric acid dimethylamine, Methanamine, N-methyl-, hydrochloride, Dimethylammonium chloride, size: 500 g
Catalog Number:
(TCD4034-5G)
Supplier:
TCI America
Description:
CAS Number: 85118-06-5
MDL Number: MFCD00010143 Molecular Formula: C7H7F2N Molecular Weight: 143.14 Purity/Analysis Method: >98.0% (GC,T) Form: Clear Liquid Boiling point (°C): 78 Flash Point (°C): 76 Specific Gravity (20/20): 1.23
Supplier:
Adipogen
Description:
The BCR-ABL oncogene triggers intracellular signaling, activating multiple transduction cascades, promoting the growth, proliferation and survival of hematopoietic cells. BCR-ABL plays a role in defective DNA repair, alteration of cellular adhesion and inhibition of apoptosis. Degregulated BCR-ABL tyrosine kinase activity is the molecular marker for CML. Inhibiting BCR-ABL tyrosine kinase activity leads to the induction of apoptosis and inhibits cellular proliferation in vitro and there are various BCR-ABL isoforms with differing activity levels as well. Dasatinib (BMS-354825, Sprycel®) is a potent multi-target kinase inhibitor of BCR-ABL. Dasatiinib performs better against ABL kinase than earlier drugs such as imatinib, and Dasatinib also is effective against SRC family of kinases, and other receptor kinases such as EPHA2, PDGFR, and c-Kit. Dasatinib's inhibiting potential against Src family kinase members is greater (IC(50) 0.5nM) than its inhibitory activity against ABL (1nM).
Supplier:
Adipogen
Description:
AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from ABL and FLT1, which were both moderately sensitive to the compound. In cells, AV-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100nM. Moreover, AV-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. In animal studies using cancer xenograft models, AV-412 (30mg/kg) demonstrated complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.
Supplier:
Adipogen
Description:
N-Tetradecanoyl-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. It appears later than shorter acyl chain AHLs in developing biofilms and, like other long chain AHLs, stimulates bacterial growth. C14-HSL also alters the proteolytic activity and enhances the migration of some strains of Proteus mirabilis. Induces violacein expression in a Chromobacterium violaceum mutant usually not able to produce homoserine lactones.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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