Pyrazine-2-carboximidamide+hydrochloride
Catalog Number:
(102980-374)
Supplier:
Adipogen
Description:
TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
Supplier:
VWR International
Description:
These Duran® flange glass heads are made with high-quality borosilicate glass.
Catalog Number:
(76262-952)
Supplier:
Rockland Immunochemical
Description:
Anti-Ezh1 Antibody was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA). Anti-EZH1 Antibody detects human EZH1. Polycomb group (PcG) proteins are essential epigenetic regulators in normal tissue homeostasis and are involved in transcriptional repression. The PcG members Ezh2 and Ezh1 are important determinants of embryonic stem cell identity, and the transcript levels of these histone methyltransferases are inversely correlated during development. Recent studies have shown that EZH1 also has histone H3K27 methyltransferase activity and binds to an overlapping subset of genes. EZH1 and EZH2 have different expression patterns. EZH2 is found in actively proliferating cells, whereas EZH1 expression is higher in nonproliferative adult tissues. EZH1 partially compensates for the loss of EZH2, as shown in cells lacking only Ezh2. In mice, EZH1 is a regulator of homeotic gene expression implicated in the assembly of repressive protein complexes in chromatin. Anti-EZH1 Antibody is ideal for investigators studying pathogenesis of hematological malignancies.
Supplier:
VWR International
Catalog Number:
(76380-328)
Supplier:
VWR International
Supplier:
VWR International
Description:
Durable round bottom flasks with 2 parallel necks.
![]()
Supplier:
VWR International
Description:
Durable round bottom flasks with 3 parallel necks.
![]()
Supplier:
VWR International
Description:
Durable round bottom flasks with 2 necks at an angle.
![]()
Catalog Number:
(89171-910)
Supplier:
VWR International
Description:
Holds (24) 25mm test tubes. Fits on VWR Base Plate for 135mm top plates
![]() ![]()
Supplier:
VWR International
Description:
Perfect for lab and plant use, this LCD digital stopwatch keeps time up to 24 hours.
Catalog Number:
(10861-558)
Supplier:
VWR International
Description:
Cell and tissue culture plates are ideal for cell growth and cell yields.
![]()
Supplier:
VWR International
Description:
Durable round bottom flasks with 3 necks at an angle.
![]()
Supplier:
VWR International
Description:
Get a seamless transition from source to system.
Supplier:
VWR International
Description:
These HDPE coated wire racks are durable for transport or sample handling.
Supplier:
VWR International
Description:
Spare Closures for VWR® Media Bottles
Supplier:
VWR International
Description:
Stand up to aggressive fluids.
![]()
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
![]()
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
![]()
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
|
|||||||||