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4-Ethoxy-3-formyl-5-methoxybenzoic+acid
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4-Ethoxy-3-formyl-5-methoxybenzoic+acid
Catalog Number:
(76077-948)
Supplier:
Bioss
Description:
The NFKB complex consists of NFKB1 or NFKB2 bound to REL, RELA, or RELB. The NFKB complex is inhibited by I kappa B proteins (NFKBIA, or NFKBIB), which inactivate NF kappa B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I kappa B proteins by kinases (IKBKA, or IKBKB,) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF kappa B complex.
Catalog Number:
(76077-946)
Supplier:
Bioss
Description:
The NFKB complex consists of NFKB1 or NFKB2 bound to REL, RELA, or RELB. The NFKB complex is inhibited by I kappa B proteins (NFKBIA, or NFKBIB), which inactivate NF kappa B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I kappa B proteins by kinases (IKBKA, or IKBKB,) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF kappa B complex.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Mannitol, Powder, U.S.P., Multi-Compendial
Supplier:
Thermo Scientific Chemicals
Description:
NMDA receptor antagonist that prevents calcium flux
Supplier:
Thermo Scientific Chemicals
Description:
Inhibits a variety of serine/threonine and tyrosine kinases including PKC
Catalog Number:
(10796-712)
Supplier:
Bachem Americas
Description:
Biotinyl-Amylin (mouse, rat), Trifluoroacetate salt, Molecular Formula: C177H286N54O55S3, Relative Molecular Mass: 4146.75, CAS Registry Number: [1678414-88-4] net, Source: Synthetic, Storage Conditions: -20 +/- 5 degree Celcius, 0.5mg
Catalog Number:
(76472-634)
Supplier:
Ohaus
Description:
Dependable benchtop micro centrifuges, ideal for high-speed laboratory applications.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
(S)-cis-Verbenol 97% (sum of isomers)
Catalog Number:
(77438-918)
Supplier:
Bioss
Description:
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
Catalog Number:
(10418-726)
Supplier:
Bioss
Description:
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011].
Supplier:
Enzo Life Sciences
Description:
A potent, irreversible inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Has been employed in in vitro and animal models for Gaucher’s disease. It raises intracellular levels of glucosylceramide by inhibiting glucosylceramidase.
Supplier:
ALADDIN SCIENTIFIC
Description:
(3R)-3-Aminobutan-1-ol ≥98%
Supplier:
Restek
Description:
Field duplicates of canister samples frequently result in analyte concentrations with high relative standard deviations.
Supplier:
Bachem Americas
Description:
Small quantities of Aβ37, 38 and 39 can be detected in CSF together with Aβ40, the most abundant Aβ homolog, Aβ42, and N-terminally truncated amyloid peptides. The relative amounts depend on the variant of Alzheimer's disease. The C-terminally truncated amyloid peptides are also found in amyloid plaques.
Catalog Number:
(10230-898)
Supplier:
Bioss
Description:
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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