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1-(2,4-Difluoro-5-hydroxyphenyl)ethanone
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1-(2,4-Difluoro-5-hydroxyphenyl)ethanone
Supplier:
BeanTown Chemical
Description:
CAS: 367-27-1; EC No: 206-688-0; MDL No: MFCD00009715
UN No: UN2921; Haz Class: 8 (4.1); Packing Group: II
Liquid/Low Melting Solid; Molecular Formula: C6H4F2O; MW: 130.09
Melting Point: 22.4°; Boiling Point: 52-53°/19 mmHg; Flash point: 57°C (135°F)
Density (g/mL): 1.362; Refractive Index: 1.486
Supplier:
AMBEED, INC
Description:
2-Bromo-3,5-difluorophenol 96%
Supplier:
Adipogen
Description:
GSK2126458 is an orally available selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) enzymesand MTOR1/2 complexes. GSK2126458 can inhibit PI3K-alpha (p85alpha/p110alpha) with IC(50) of 0.04nM. GSK2126458 has Ki values in the picomolar range for each of the class I PI3K isoforms and MTOR1/2 complexes. GSK2126458 has potent in vitro and in vivo growth-inhibitory effects on cancer cells. In comparison with other clinical PI3K inhibitors, GSK2126458 is around 100-fold more potent than BEZ235 (6nM). GSK2126458 also a low picomolar inhibitor of the common activating mutants of p110R ( E542K, E545K, and H1047R ) with Ki of 0.008nM, 0.008nM and 0.009nM in human cancer. In mechanistic cellular assays, GSK2126458 caused a significant reduction in the levels of pAKT-S473 with remarkable potency. Consistent with its activity against both PI3K R and mTOR, GSK2126458 also inhibits phosphorylation of AKT-T308 and p70S6K at low nanomolar concentrations. GSK2126458 induces a G1 cell cycle arrest and inhibits cell proliferation in a large panel of cell lines, including T47D and BT474 breast cancer lines.
Catalog Number:
(TS41190-0250)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
2-Hydroxyacetophenone 97%
Supplier:
TCI America
Description:
CAS Number: 60-81-1
MDL Number: MFCD00006591 Molecular Formula: C21H24O10 Molecular Weight: 436.41 Purity/Analysis Method: >97.0% (T) Form: Crystal Specific rotation [a]20/D: -54 deg (C=3.2, EtOH(95vol%))
Catalog Number:
(AA42013-06)
Supplier:
AMBEED, INC
Description:
3-(4-Hydroxyphenyl)-1-propanol 95%
Supplier:
AMBEED, INC
Description:
2-Bromo-4,6-difluoroaniline 96%
Supplier:
AMBEED, INC
Description:
3-(3-Hydroxyphenyl)propionic acid 98%
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
D-(-)-α-(4-Hydroxyphenyl)glycine 98+%
Supplier:
AMBEED, INC
Description:
S-(4-Hydroxyphenyl) 4-hydroxybenzenesulfinothioate, Purity: 97%, CAS Number: 94971-84-3, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 250MG
Supplier:
Matrix Scientific
Description:
2-Hydroxyphenyl benzenecarboxylate 95
Catalog Number:
(101921-514)
Supplier:
Matrix Scientific
Description:
N-(3-Chloro-2-hydroxyphenyl)acetamide
Supplier:
AMBEED, INC
Description:
N-(4-Hydroxyphenyl)maleimide 98%
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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