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N\\\\\\\'-[1-Cyclobutylaminopropylidene]hydrazinecarboxylic+acid-
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N\\\\\\\'-[1-Cyclobutylaminopropylidene]hydrazinecarboxylic+acid-
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 043283-500MG , MDL Number: MFCD02082817
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 045197-500MG , MDL Number: MFCD08056649
Catalog Number:
(10239-790)
Supplier:
Bioss
Description:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
Catalog Number:
(77684-633)
Supplier:
AMBEED, INC
Description:
Ethyl-2,3-butadienoate 97%, Ambeed.Inc
Supplier:
BeanTown Chemical
Description:
CAS: 609-15-4; EC No: 210-180-4; MDL No: MFCD00009141
UN No: UN2920; Haz Class: 8 (3); Packing Group: II
Liquid; Molecular Formula: C6H9ClO3 ; MW: 164.59
Boiling Point: 107°/14 mmHg; Flash point: 54°C (129°F)
Density (g/mL): 1.19; Refractive Index: 1.441
Supplier:
Matrix Scientific
Description:
MF=C12H13NO2 MW=203.24 CAS=778-82-5 MDL=MFCD00005635 5G
Catalog Number:
(75844-432)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.
Catalog Number:
(75843-846)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
Catalog Number:
(75844-300)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.
Catalog Number:
(75843-624)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The 1A8 monoclonal antibody specifically reacts with the 21-25 kDa glycophosphatidylinositol-anchored protein known as Ly-6G, expressed by the granulocytes from the bone marrow and periphery neutrophils. Ly-6G and Ly-6C form the Granulocyte Receptor-1 antigen (GR-1). The binding of the 1A8 antibody to the Ly-6G can be blocked by another antibody, RB6-8C5, which also recognizes Ly-6C. While 1A8 is specific for only Ly-6G, RB6-8C5 also binds to Ly-6C.
Catalog Number:
(102840-368)
Supplier:
Matrix Scientific
Description:
Ethyl-6-hydroxy-2-naphthoate ≥97%
Supplier:
AMBEED, INC
Description:
1-[2-(Dimethylamino)ethyl]-1H-pyrazole-4-carboxylic acid 95%
Supplier:
AOB CHEM USA
Description:
Ethyl 2-(3-Cyanophenyl)-2,2-difluoroacetate ≥97%
Supplier:
AMBEED, INC
Description:
Ethyl-4-chloro-3-nitrobenzoate 98%
Supplier:
Matrix Scientific
Description:
Ethyl thiophenene-3-glyoxylate ≥97%
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 012666-5G , MDL Number: MFCD00044769
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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