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1-Ethyl-2,5-difluoro-4-methoxybenzene
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1-Ethyl-2,5-difluoro-4-methoxybenzene
Catalog Number:
(10669-868)
Supplier:
Bioss
Description:
Tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein 1 (IFP1), is a 488 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Three isoforms of TRIM34 exist as a result of alternative splicing events. Isoform 1, the most abundant isoform, is highly expressed in placenta, spleen, colon and peripheral blood leukocytes. Studies have shown that Interferon (IFN) stimulation leads to an upregulation of TRIM34. These findings suggest that TRIM34 maybe a downstream effector that mediates IFN activities.
Catalog Number:
(10259-064)
Supplier:
Bioss
Description:
The galanin family of proteins are key members for inflammatory processes and cell proliferation, and may function as potential biomarkers for colon cancer. Produced in both neuronal and nonneuronal cells in the skin, members of the galanin family include galanin, galanin-message associated peptide, galanin-like peptide and alarin. GALP, also known as galanin-like peptide, is a 116 amino acid secreted protein belonging to the galanin family. Mainly produced in the arcuate nucleus of the hypothalamus (ARC) and the posterior pituitary, GALP is thought to function in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion. GALP binds to the G-protein coupled galanin receptors, including GALR1, GALR2 and GALR3, and may also play a role in energy metabolism, with significant implications towards obesity. GALP exits as two alternatively spliced isoforms.
Catalog Number:
(10665-128)
Supplier:
Bioss
Description:
The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
Supplier:
Matrix Scientific
Description:
Ethyl-5-ethylisoxazole-3-carboxylate
Catalog Number:
(76109-476)
Supplier:
Bioss
Description:
GIPC2 is a 315 amino acid protein that localizes to the cytoplasm and contains one PDZ domain. Expressed at high levels in kidney and colon and at lower levels in adult liver, GIPC2 interacts with SEMA5A and is thought to function as a scaffold protein, possibly modulating cell adhesion and growth factor signaling and playing a role in tumorigenesis. The gene encoding GIPC2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Catalog Number:
(75790-878)
Supplier:
Prosci
Description:
Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, lung, kidney, stomach, colon, and breast. It is related to Epidermal Growth Factor (EGF) and Transforming Growth Factor Alpha (TGF-alpha). As an EGF-related growth factor, AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. AREG may also play a protective role in Bleomycin-Induced Pneumopathy.
Supplier:
PeproTech, Inc.
Description:
APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of the colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, competes for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines, including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF-like receptor binding of the APRIL precursor. Recombinant Human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.
Supplier:
Biotium
Description:
This MAb recognizes full-length MUC1 in a glycosylation-independent manner and can bind to the fully glycosylated protein. The dominant epitope of this MAb is APDTR in the VNTR region. It reacts with the core peptide of the MUC1 protein, which is a member of a family of mucin glycoproteins that are characterized by high carbohydrate content, O-linked oligosaccharides, high molecular weight (>200 kDa) and an amino acid composition rich in serine, threonine, proline and glycine. The core protein contains a domain of 20 amino-acid tandem repeats that functions as multiple epitopes for the MAb. Incomplete glycosylation of some tumor-associated mucins may lead to variable unmasking of the multiple peptide epitopes leading to the observed differences in staining intensity between normal and malignant tissues. This MAb reacts with both normal and malignant epithelia of various tissues including breast and colon.
Catalog Number:
(10430-174)
Supplier:
Bioss
Description:
SPARC (secreted protein acidic and rich in cysteine) is a phosphorylated, acidic, glycine-rich glycoprotein that is secreted by endothelial cells and is present in large amounts in the parietal endoderm of mouse embryos and in human placenta. SPARC-like protein 1 (SPARCL1), also known as high endothelial venule protein (Hevin) or MAST9, is a 664 amino acid member of the SPARC family of proteins. Highly expressed in lymph node, heart, lung, brain, skeletal muscle, ovary, colon and small intestine, SPARCL1 is a secreted protein that contains one EF-hand domain, one follistatin-like domain and one Kazal-like domain. SPARCL1 is implicated to play a role in neuronal remodeling and tumor suppression. The gene encoding SPARCL1 maps to chromosome 4q22.1.
Catalog Number:
(10750-052)
Supplier:
Prosci
Description:
Plxdc2 Antibody: Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57% amino acid identity to TEM7, the most abundant tumor endothelial marker. Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung. Plxdc2 and TEM7 may be important for tumor angiogenesis in humans. Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors.
Catalog Number:
(76117-044)
Supplier:
Bioss
Description:
SPARC (secreted protein acidic and rich in cysteine) is a phosphorylated, acidic, glycine-rich glycoprotein that is secreted by endothelial cells and is present in large amounts in the parietal endoderm of mouse embryos and in human placenta. SPARC-like protein 1 (SPARCL1), also known as high endothelial venule protein (Hevin) or MAST9, is a 664 amino acid member of the SPARC family of proteins. Highly expressed in lymph node, heart, lung, brain, skeletal muscle, ovary, colon and small intestine, SPARCL1 is a secreted protein that contains one EF-hand domain, one follistatin-like domain and one Kazal-like domain. SPARCL1 is implicated to play a role in neuronal remodeling and tumor suppression. The gene encoding SPARCL1 maps to chromosome 4q22.1.
Catalog Number:
(10430-804)
Supplier:
Bioss
Description:
SPARC (secreted protein acidic and rich in cysteine) is a phosphorylated, acidic, glycine-rich glycoprotein that is secreted by endothelial cells and is present in large amounts in the parietal endoderm of mouse embryos and in human placenta. SPARC-like protein 1 (SPARCL1), also known as high endothelial venule protein (Hevin) or MAST9, is a 664 amino acid member of the SPARC family of proteins. Highly expressed in lymph node, heart, lung, brain, skeletal muscle, ovary, colon and small intestine, SPARCL1 is a secreted protein that contains one EF-hand domain, one follistatin-like domain and one Kazal-like domain. SPARCL1 is implicated to play a role in neuronal remodeling and tumor suppression. The gene encoding SPARCL1 maps to chromosome 4q22.1.
Catalog Number:
(102839-976)
Supplier:
Matrix Scientific
Description:
Ethyl-3,6-dichloropyridazine-4-carboxylate ≥97%
Catalog Number:
(77440-790)
Supplier:
Bioss
Description:
EVPLL (envoplakin-like protein) is a 301 amino acid protein that belongs to the plakin or cytolinker family. The gene encoding EVPLL maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Catalog Number:
(10272-944)
Supplier:
Bioss
Description:
Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A); chromogranin B (Chr-B), also known as secretogranin I; chromogranin C (also known as secretogranin II or Sg II); and secretogranin III (Sg III or SCG3). High levels of Chr-A expression are characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms; the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.
Catalog Number:
(10748-982)
Supplier:
Prosci
Description:
Cell adhesion molecule 3 (CADM3) is a member of a family of immunoglobulin-like, calcium-independent cell-cell adhesion molecules. CADM3 localizes to non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes and is thought to play an important role in the formation of synapses, axon bundles and myelinated axons. Recently, CADM3 has been shown to suppress the growth and tumorigenic ability of colon cancer cells, indicating that it can act as a tumor suppressor.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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