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N2-[3-(Dimethylamino)propyl]-2,3-pyridinediamine+hydrochloride
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N2-[3-(Dimethylamino)propyl]-2,3-pyridinediamine+hydrochloride
Catalog Number:
(RK30062)
Supplier:
Restek
Description:
Mix contains: 1,2-Dibromo-3-chloropropane (DBCP) (96-12-8), 1,2-Dibromoethane (EDB) (106-93-4).
Supplier:
APOLLO SCIENTIFIC
Description:
3,5-Dichlorobenzyl alcohol
Supplier:
Adipogen
Description:
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. Aurora A and B are essential in mitosis. Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. The role of Aurora C is unclear; however, Aurora C can complement Aurora B kinase activity in mitosis. SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. A cocrystal structure of SNS-314 with Aurora A confirms that SNS-314 engages the purine-binding pocket of Aurora. SNS-314 inhibits cellular proliferation in the HCT116 colorectal carcinoma cell line with an EC50 of ~5nM. Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. Administration of SNS-314 to HCT116 tumor bearing mice potently suppresses tumor growth. Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent.
Catalog Number:
(SXLCS-4951)
Supplier:
SPEX CERTIPREP LLC
Description:
LC & LC/MS single-component organic standard.
Supplier:
Thermo Scientific Chemicals
Description:
Solution is micro-filtered and supplied in ampules. RNase and DNase free.
Supplier:
BeanTown Chemical
Description:
CAS: 2766-43-0; MDL No: MFCD00191869
Liquid; Molecular Formula: C9H17NO5; MW: 219.23
Flash point: <gt/>110°C (<gt/>230°F)
Density (g/mL): 1.082; Refractive Index: 1.452; Optical Rotation: [α]20/D −18°, c = 5 in methanol
Supplier:
Matrix Scientific
Description:
MF=C13H19Bo3 MW=234.11 Cas=443776-76-9 MDL=MFCD09266196 ,25G
Supplier:
APOLLO SCIENTIFIC
Description:
2,4-Dimethoxybenzyl alcohol
Catalog Number:
(RK31026)
Supplier:
Restek
Description:
Standards are packaged at a concentration of 2000 µg/mL in a 1 mL ampule.
Catalog Number:
(TCD3758-5G)
Supplier:
TCI America
Description:
CAS Number: 20880-92-6
MDL Number: MFCD00022183
Molecular Formula: C12H20O6
Molecular Weight: 260.29
Purity/Analysis Method: <gt/>98.0% (GC)
Form: Crystal
Melting point (°C): 96
Specific rotation [a]20/D: -34 deg (C=1, H2O)
Storage Temperature: <lt/>0°C
Catalog Number:
(SXS-4155)
Supplier:
SPEX CERTIPREP LLC
Description:
Consumer safety standards, phthalates in polyethylene QC standards.
Supplier:
MP Biomedicals
Description:
Cupric sulfate pentahydrate is a common inorganic salt used in analytical chemistry, organic synthesis, and in art to etch zinc plates.
Supplier:
Thermo Scientific Chemicals
Description:
MDL: MFCD00149681
Notes: m.p. 30°C -2H2O, 110°C -4H2O, 250°C anhydrous; ñ 2.286
Soluble in water, methanol, glycerol.
Fieser: 1,164 2,89 5,162 6,141 10,107 19,111
Supplier:
Thermo Scientific Chemicals
Description:
2 3:4 5-Di-O-Isopropylidene-Beta-D-Fructopyranose, Purity: 98%, CAS number: 20880-92-6, Molecular Formula: C12H20O6, Color: white, Form:Powder, Synonyms: Diacetone-D-fructose2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose, Size: 10g
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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