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3,3-Dimethylpiperidin-4-one+hydrochloride
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3,3-Dimethylpiperidin-4-one+hydrochloride
Supplier:
Adipogen
Description:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. Anti-IL-33, mAb (recombinant) (blocking) (Bondy-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
Supplier:
AMBEED, INC
Description:
(S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione, Purity: 98%, CAS Number: 1323403-33-3, Appearance: White to off-white solid, Storage: Sealed in dry, Store in freezer, under -20 C, Size: 2mg
Supplier:
AMBEED, INC
Description:
3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol, Purity: 98+%, CAS Number: 575474-82-7, Appearance: Solid, Storage: Keep in dark place, Inert atmosphere, 2-8 C, Size: 10mg
Supplier:
Strem Chemicals Inc
Description:
CAS #: 13782-33-7. Size: 1g.
Supplier:
AOB CHEM USA
Description:
3-Chloro-2-hydroxy-4-(trifluoromethyl)benzoic acid ≥97%
Catalog Number:
(77409-886)
Supplier:
APOLLO SCIENTIFIC
Description:
3-Methylcrotonic acid 98%
Supplier:
TCI America
Description:
CAS Number: 403-33-8
MDL Number: MFCD00017959 Molecular Formula: C8H7FO2 Molecular Weight: 154.14 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Boiling point (°C): 197 Flash Point (°C): 77 Specific Gravity (20/20): 1.20
Catalog Number:
(89155-112)
Supplier:
Enzo Life Sciences
Description:
Host: Mouse, Isotype: IgG1
Supplier:
Matrix Scientific
Description:
MF=C15H32Sn MW=331.11 Cas=24850-33-7 25G
Supplier:
TCI America
Description:
CAS Number: 2067-33-6
MDL Number: MFCD00004414 Molecular Formula: C5H9BrO2 Molecular Weight: 181.03 Purity/Analysis Method: >97.0% (GC,T) Form: Crystal Boiling point (°C): 152 Melting point (°C): 40 Flash Point (°C): 110 Storage Temperature: 0-10°C
Supplier:
AMBEED, INC
Description:
2-(2-Isopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, Purity: 95+%, CAS number: 852110-33-9, Appearance: Solid, Storage: Sealed in dry, Room Temperature, Size: 1G
Catalog Number:
(10072-012)
Supplier:
Prosci
Description:
Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5).
Supplier:
AMBEED, INC
Description:
(11bS)-4-Hydroxy-2,6-bis(4-nitrophenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepine 4-oxide, Purity: 98% 99%ee, CAS Number: 878111-16-1, Appearance: White to yellow powder or crystals, Storage: Inert atmosphere, 2-8 C, Size: 250mg
Supplier:
Strem Chemicals Inc
Description:
CAS #: 7440-33-7. Size: 50g.
Supplier:
MORAVEK BIOCHEMICALS MS
Description:
Suramin hexasodium
Catalog Number:
(103648-768)
Supplier:
Sino Biological
Description:
Produced in rabbits immunized with purified, recombinant Human IL-33 (rh IL-33; Catalog#10368-HNAE; Ser 112-Thr 270; NP_254274.1). Total IgG was purified by Protein A affinity chromatography.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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