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2-[(2-Ethoxy-2-oxoethyl)sulfanyl]benzenecarboxylic+acid
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2-[(2-Ethoxy-2-oxoethyl)sulfanyl]benzenecarboxylic+acid
Catalog Number:
(75791-614)
Supplier:
Prosci
Description:
Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesized in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.
Catalog Number:
(102519-378)
Supplier:
Matrix Scientific
Description:
MF=C8H3FIN3 MW=287.04 MDL=MFCD20487094 250MG
Catalog Number:
(102519-386)
Supplier:
Matrix Scientific
Description:
MF=C8H4CLIN2O MW=306.49 MDL=MFCD20487111 250MG
Catalog Number:
(77031-630)
Supplier:
AMBEED, INC
Description:
tert-Butyl octahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate 95%
Supplier:
AMBEED, INC
Description:
(4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, Purity: 97%, CAS Number: 1146629-77-7, Appearance: White to yellow powder or crystals, Storage: Sealed in dry, 2-8 deg C, Size: 250mg
Supplier:
AMBEED, INC
Description:
tert-Butyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1-carboxylate, Purity: 95%, CAS Number: 877060-48-5, Appearance: Light yellow to yellow powder or crystals, Storage: Keep in dark place, Sealed in dry, 2-8C, Size: 1G
Catalog Number:
(10750-320)
Supplier:
Prosci
Description:
Dact2 Antibody: The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
Supplier:
Matrix Scientific
Description:
MF=C13H9BRN2 MW=273.14 CAS=953414-75-0 MDL=MFCD11109822 1G
Catalog Number:
(101918-330)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 059526-250MG , MDL Number: MFCD18803508
Catalog Number:
(77135-576)
Supplier:
AMBEED, INC
Description:
(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, Purity: 97%, CAS Number: 1146629-75-5, Appearance: Solid, Storage: Inert atmosphere, 2-8 deg C, Size: 5g
Catalog Number:
(101931-108)
Supplier:
Matrix Scientific
Description:
MF=C12H12N2O2 MW=216.24 Cas=18877-34-4 MDL=MFCD00835301 ,500Mg
Catalog Number:
(101918-096)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 059410-250MG , MDL Number: MFCD17171346
Catalog Number:
(101833-482)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 032329-250MG , MDL Number: MFCD09965903
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 053883-500MG , MDL Number: MFCD13562962
Supplier:
AMBEED, INC
Description:
2-Methyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine hydrochloride, Purity: 95%, CAS Number: 1893457-62-9, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 1G
Catalog Number:
(101917-962)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 059343-250MG , MDL Number: MFCD17171312
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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