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2-Formylphenylboronic+acid
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2-Formylphenylboronic+acid
Supplier:
VWR International
Description:
Really versatile general purpose mid-polarity phase for a wide range of applications. Ideal in confirmation analysis.
Catalog Number:
(97063-774)
Supplier:
VWR
Description:
A concentrated solution prepared with Biotechnology Grade powder for convenient use in nucleic acid and protein purification procedures.
Catalog Number:
(97063-754)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
GMP manufactured product. The infrared spectrum conforms to the standard.
Catalog Number:
(89359-772)
Supplier:
Genetex
Description:
The transcription factor NFkB is widely recognized as a critical mediator of immune and inflammatory responses. In most cell types, NFkB is found in the cytoplasm where it is associated with an inhibitory protein known as IkB. An impressive variety of stimuli (tumor necrosis factor, interleukin 1, T-cell activation signals, bacterial endotoxins, viral transforming proteins, certain growth factors and reactive oxygen intermediates) lead to the rapid nuclear accumulation of NFkB by the induced phosphorylation and subsequent degradation of IkB. In the nucleus, NFkB regulates genes encoding cytokines, cytokine receptors, cell adhesion molecules, proteins involved in coagulation and genes involved in cell growth control. Additionally, NFkB is thought to be an important transcriptional regulator for HIV. Growing evidence indicates that the dysregulation of NFkB may be key to a number of diseases including arthritis and other inflammatory diseases, Alzheimer's disease, atherosclerosis and cancer.
Supplier:
VWR
Description:
Reagent for stabilization of buffer formulations and electrophoresis of biological molecules.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
For liquid chromatography and molecular biology applications.
Supplier:
Adipogen
Description:
In recent years several groups have studied the sequence requirements, specificity, signaling pathways and kinetics of the TLR (Toll-like receptor) 9 suppression by inhibitory oligonucleotide motifs, which led to a class of novel inhibitory oligonucleotide (iODNs), that is independent of the previously thought species preference. Subsequently it has been discovered that telomeric DNA repeats (TTAGGG)n can block immune activation by CpG-ODNs. Short, 11-15 base long oligonucleotides were synthesized that were capable of potently inhibiting CpG-stimulation. The optimal inhibitory DNA motif consists of a pyrimidine-rich triplet, preferably CCT, which is positioned 5- to the GGG sequence in a singlestranded DNA molecule. Additionally, both the optimal spacing between the CCT and GGG motifs, as well as their relative order to each other, is of crucial importance for the inhibitory DNA action. Interestingly, although both TLR7/TLR8 ligands and bacterial DNA share the endosomal compartment for receptor binding and signal transduction, certain iODNs (G-type) suppress only TLR9-mediated activation, whereas prototype class I iODN may also interfere with the activation via the TLR7/TLR8 pathway. Recently, intriguing evidence has been presented that for some iODN classes the immuno-modulatory biological activity shows only limited sequence dependency or may not even involve TLR-mediated uptake and signaling pathways. For example iODNs of the class II are thought to act on immune activation through inhibition of STAT signaling and independent of TLR signaling via binding to a yet to be identified 'ODN-receptor'. Slightly modified phosphodiester versions of the most potent inhibitory ODNs were also able to profoundly block the immune activation of macrophages and just recently prove to be valuable tools for in vivo use in experimental animal models of inflammatory and auto-immune diseases. Based upon these recent insights the following classification for iODNs has been suggested: Class I: G-stretch ODNs: TLR9-specific competitors, some iODNs may also affect TLR7 and TLR8 signalingClass II: ODNs with telomeric repeats: TLR-independent inhibitors of STAT signaling (cellular uptake via an 'ODN receptor'?)Class III: Inhibitors of DNA uptake in a sequence independent mannerClass IV: Long phosphorothioate ODNs as direct competitors of TLR9 signaling in a sequence independent manner
Supplier:
Adipogen
Description:
Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest).
Supplier:
TCI America
Description:
CAS Number: 25137-01-3
MDL Number: MFCD03093637 Molecular Formula: C8H15NO2 Molecular Weight: 157.21 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 110 Flash Point (°C): 90 Specific Gravity (20/20): 1.02 Specific rotation [a]20/D: -1.5 deg (neat) Storage Temperature: 0-10°C
Catalog Number:
(10232-506)
Supplier:
Bioss
Description:
This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K >substance K >substance P.
Supplier:
Omega Bio-Tek
Description:
Achieve fast and reliable purification of DNA or RNA with a relatively small elution volume of 10–15µL
Supplier:
VWR International
Description:
Proprietary low-polarity and low-bleeding stationary phase; great choice for pesticides, herbicides, polychlorinated biphenyls (PCBs), and polyaromatic hydrocarbons (PAHs). Ideal for GC/MS applications and is also an excellent choice as a confirmation column for semivolatile environmental analysis.
Supplier:
VWR International
Description:
General purpose column with added high temperature stability for the analysis of Pesticides, PCBs, substituted polar compounds, phenols, etc.
Supplier:
Thermo Scientific Chemicals
Description:
D-Aspartic acid 1-methyl ester, Purity: 98%, Cas number: 65414-78-0, Molecular formula: C5H9NO4, Color: Pale Yellow, Form: Powder, Synonyms: H-D-Asp-Ome, 5G
Catalog Number:
(26316-726)
Supplier:
VWR International
Description:
40-60um fritted glass support base is compatible with the VWR* 47mm Filter Holder with 40/35 Standard Taper Joint Connection.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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