Text Search >
2-(2-Methyl-1-piperidinyl)isonicotinic+acid
Print…
You Searched For:
188,079 results were found
2-(2-Methyl-1-piperidinyl)isonicotinic+acid
Supplier:
Enzo Life Sciences
Description:
The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation.
The catalytic core of this unusually large (2000kDa, 450Å in length) complex (31 subunits) is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. 20S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome. The 19S regulatory subunit recognizes ubiquitinated proteins and plays an essential role in unfolding and translocating targets into the lumen of the 20S subunit. A second activator which can associate with the 20S proteasome in the absence of ATP is known as PA28 or the 11S regulator. The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (recently referred to as PA28γ). These subunits, with an apparent relative molecular weight of approximately 29kDa, form ringlike heteromeric complexes of ~200kDa possibly with an α3β3 stoichiometry. Electron microscopic studies have shown PA28 to be a ring shaped particle which, like the 19S, caps the 20S proteasome, by binding to the α-rings, at both or either end. The complex may, however, be readily dissociated. The finding that PA28 modulates the proteasome-catalysed production of antigenic peptides presented to the immune system on MHC class I molecules indicates a cellular function of this activator in antigen processing. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.
Supplier:
VWR
Description:
A protease inhibitor of arginine-selective enzymes like trypsin, kallikrein and thrombin.
Catalog Number:
(66130-153)
Supplier:
LaMotte
Description:
Chlorine pH test kit is used for testing for free available chlorine, monochloramine, dichloramine, total residual chlorine, and pH using DPD tablets, phenol red tables and the octa-slide 2 comparator.
Supplier:
BeanTown Chemical
Description:
CAS: 2216-51-5; EC No: 218-690-9; MDL No: MFCD00062979; RTECS: OT0700000
Crystalline; Molecular Formula: C10H20O; MW: 156.27
Melting Point: 41-45°; Boiling Point: 212°; Flash point: 101°C (214°F)
Optical Rotation: [α]20/D -50°, c = 10 in ethanol
Supplier:
AMBEED, INC
Description:
(R)-(-)-1,3-Butanediol 97%
Supplier:
Adipogen
Description:
Metal-organic frameworks (MOFs).
Supplier:
TCI America
Description:
Nelfinavir Mesylate Hydrate, Purity: >97.0%(HPLC), CAS Number: 159989-65-8, Molecular Formula: C32H45N3O4S.CH4O3S.xH2O, Molecular Weight: 663.89(as Anhydrous), Synonyms: Nelfinavir Methanesulfonate Hydrate, Size: 25MG
Supplier:
TCI America
Description:
CAS Number: 2216-51-5
MDL Number: MFCD00062979 Molecular Formula: C10H20O Molecular Weight: 156.27 Purity/Analysis Method: >99.0% (GC) Form: Crystal Boiling point (°C): 216 Melting point (°C): 43 Flash Point (°C): 85 Specific rotation [a]20/D: -50 deg (C=10, EtOH)
Supplier:
VWR International
Description:
Supplied with red cap and PTFE Seal for high temperature procedures. 35 x 100 mm.
Supplier:
VWR
Description:
TCEP-HCl (Tris(2-carboxyethyl)phosphine hydrochloride) for biotechnology
Catalog Number:
(SXCL-INT-B4)
Supplier:
SPEX CERTIPREP LLC
Description:
CLP Standards for ICP & ICP-MS
Our Contract Laboratory Program (CLP) standards allow you to Calibrate with Confidence®. The standards are to be used in conjunction with the Statement of Work for Inorganic Analysis; Multi-Media/Multi-Concentration Document Number ILM 05.3/ISM 01.2. The final ICP check, performed in our own laboratories, is your stamp of assurance. We calibrate our instruments with traceable reference materials and show you the actual found value of the solution you receive, not just an ideal, calculated number as so many other standards manufacturers do. The combination of elements, concentrations and matrices listed have been diagnosed by SPEX CertiPrep for convenience of use and stability. US EPA SOW ILM 05.3/ISM 01.2 gives specific procedures for the methods of analysis, target elements, and concentrationlevels. Standards are specified not only by the elements present and their relative concentrations, but also the order and frequency of running standards, blanks and samples. Details of these specifications may be found in the US EPA SOW ILM 05.3/ISM 01.2 in the following sections: • Exhibit C, Inorganic Target Analyte List (TAL) • Exhibit D, Analytical Methods • Exhibit E, QA/QC Requirements CLP ISM 01.2 and ILM 05.2 & 05.3 Standards for ICP-MS For verification of inter-element and background correction factors at the beginning and the end of each analysis run. In addition, a verification must be done after every 20th sample. Two solutions are required for the most common interference check: Solution A, the interferents alone (CL-INT-A2) and Solution AB, a combination of interferents (CL-INT-A2) and analytes (CL-INT-B3 or CL-INT-B4). Solution A is prepared by diluting CL-INT-A2 10-fold. Solution AB is prepared by diluting CL-INT-A2 10-fold and CL-INT-B3 or CL- INT-B4 100-fold; for example, 10 ml of CL-INT-A2 and 1 ml of CL-INT-B3 or CL-INT-B4 into a 100 ml volumetric flask, brought to volume with a matrix blank. Once prepared, the solutions should be analyzed consecutively, starting with Solution A.
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
TRIS Hydrochloride, Biotech Reagent
Catalog Number:
(JT4126-07)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
TRIS HCl (tris(hydroxymethyl)aminomethane hydrochloride) ≥99.0%, Biotech Reagent
Catalog Number:
(97063-774)
Supplier:
VWR
Description:
A concentrated solution prepared with Biotechnology Grade powder for convenient use in nucleic acid and protein purification procedures.
Supplier:
BeanTown Chemical
Description:
CAS: 868-14-4; EC No: 212-769-1; MDL No: MFCD00065392; RTECS: WW8223000
Powder; Linear Formula: KOOCCH(OH)CH(OH)COOH; Molecular Formula: C4H5KO6; MW: 188.18
Melting Point: <gt/>250°
Density (g/mL): 1.954; Optical Rotation: [α]20/D +10°, c = 2 in 10% HCl
Supplier:
VWR
Description:
Reagent for stabilization of buffer formulations and electrophoresis of biological molecules.
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
|
|||||||||
List View
