Text Search >
4-Bromo-5-(trifluoromethyl)-1H-indazole
Print…
You Searched For:
27,125 results were found
4-Bromo-5-(trifluoromethyl)-1H-indazole
Supplier:
Adipogen
Description:
Potent immunosuppressant with anti-inflammatory and antitumor properties. Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators. Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH). Human dCTP pyrophosphatase 1 inhibitor. Interferes with a number of transcription factors including p53, NF-kappaB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1). Shown to inhibit aromatase activity. Shows antifertility activity and antipolycystic kidney disease effects.
Supplier:
MP Biomedicals
Description:
Trichloroacetic acid is used in protein precipitation; has been used to determine protein concentration by quantitative precipitation.
Supplier:
Adipogen
Description:
Antidiabetic agent. Potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor. <gt/>300-fold selectivity over SGLT-1, 4, 5 and 6. SGLT-2 is found almost exclusively in the proximal tubules of nephronic components in kidneys. Inhibition of SGLT-2 reduces blood glucose by blocking renal glucose reabsorption and thereby increasing urinary glucose excretion (UGE). Shown to preserves beta cell mass and restore glucose homeostasis.
Supplier:
Adipogen
Description:
Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion
Supplier:
Adipogen
Description:
NVP-BEZ235 is an imidazo[4,5-c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. In cellular settings using human tumor cell lines, this molecule is able to effectively and specifically block the dysfunctional activation of the PI3K pathway, inducing G1 arrest at IC(50) values 3-10nM in biological cell growth and viability assays. In addition NVP-BEZ235 shows effective IC(50) values in in vitro tests against mTor and PI3K family members of 10nM.
Catalog Number:
(IC15727780)
Supplier:
MP Biomedicals
Description:
Guaiacol is a phenolic natural product first isolated from Guaiac resin, as well as the oxidation of lignin. It is readily oxidized by the heme iron of peroxidases including the peroxidase of cyclooxygenase (COX) enzymes. Guaiacol is able to inhibit prostaglandin biosynthesis like a classic NSAID, but it does not induce gastric damage.
Catalog Number:
(PAA7640)
Supplier:
Promega Corporation
Description:
The Wizard® Plus Midipreps DNA Purification System isolates plasmid DNA in 90 minutes or less, yielding up to 200μg of high-quality DNA with no organic extractions or ethanol precipitations.
Supplier:
MP Biomedicals
Description:
Chloroform is a common laboratory reagent favored for use as a solvent due to the compounds relative unreactivity and miscibility with most organic compounds. Chloroform is a colorless, volatile chlorinated organic solvent whose vapors have a narcotic effect.
Chloroform is use as a solvent for fats, oils, rubber, alkaloids, waxes, gutta-percha, resins; as cleansing agent; in fire extinguishers to lower the freezing temperature of carbon tetrachloride. Procedures have been described for the use of chloroform in lambda plaques storage, lambda cDNA storage, the removal of mineral oil from PCR reaction samples, oligonucleotide purification, a hydroxyl radical footprinting protocol, a transcriptional run-on assay protocol, and an overlay assay for beta-galactosidase activity. It has also been used with phenol in such procedures as DNA recovery from polyacrylamide gels, ethidium bromide removal from DNA preparations, lysis protocols for plasmid DNA isolation, RNase removal, and purification of yeast DNA. A protocol describes the use of chloroform in a high-performance thin-layer chromatography protocol for sphingomyelin analysis. Chloroform can also be used in chloroform/methanol mixtures for the isolation of cardiolipids from Geobacillus stearothermophilus and their subsequent MS analysis. The isolation of the bacteriocin amylovorin L471 from Lactobacillus amylovorus DCE 471 in culture broth has been reported, using chloroform/methanol extraction and precipitation in the procedure. Chloroform/2-butanol mixtures can be used for the extraction of steroid sulfates for analysis by nanoelectrospray ionization mass spectrometry. Physical Appearance: Liquid Vapor Density: 4.36 (air = 1) (Lit.) Vapor Pressure: 211 hPa at 20 °C(Lit.) Refractive Index: n20/D 1.445(Lit.) Solubility: Soluble in water (1 mL/200 mL water); miscible with ethanol, benzene, ether, petroleum ether, carbon tetrachloride, carbon disulfide, oils.
Supplier:
Promega Corporation
Description:
A simple, reliable, silica-resin-based method for rapid isolation of plasmid DNA on a miniprep scale. No organic extraction or ethanol precipitation required. Extraction completed in 15 minutes.
Catalog Number:
(PAA7710)
Supplier:
Promega Corporation
Description:
System for purification of single-stranded DNA from whole blood or blood stains. DNA may be used directly in amplification reactions without further manipulation. No organic extraction or ethanol precipitation.
Supplier:
MP Biomedicals
Description:
Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis.
Supplier:
Corning
Description:
AxyPrepâ„¢ Mag plasmid purification Kit utilizes a magnetic bead technology for high throughput purification of plasmid DNA from <i>E.coli</i> cells. The AxyPrepâ„¢ Mag kit can also be used with fosmid and BAC vector-based constructs ranging from 5 to 150 Kb. The system consists of steps of pelleting cells, resuspension, lysis, neutralization, DNA binding, ethanol washing and plasmid elution. The protocol is automation-compatible.
Supplier:
Adipogen
Description:
Water soluble, irreversible serine protease (chymotrypsin, kallikrein, plasmin, thrombin and trypsin) inhibitor. Stable, non-toxic alternative to PMSF. Potent, selective inhibitor of Site-1-protease (S1P). Used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation by selectively inhibiting S1P. NAD(P)H oxidase inhibitor. Inhibits activation of TGFbeta and activates JNK and p38 MAP kinases. beta-Secretase inhibitor. Shown to inhibit beta-amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations.
Supplier:
MP Biomedicals
Description:
Sulfobromophthalein (BSP) is a dye with a high affinity for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.
Sulfobromophthalein (BSP) is used in diagnosis of hepatic disorders. It is also used for the quantitative determination of proteins.
Catalog Number:
(IC15518325)
Supplier:
MP Biomedicals
Description:
Leishman's stain, also Leishman stain, is used in microscopy for staining blood smears. It provides excellent stain quality. It is based on a methanolic mixture of "polychromed" methylene blue (i.e. demethylated into various azures) and eosin.
Supplier:
Adipogen
Description:
p56lck protein kinase inhibitor. Competitive casein kinase II (CK2) inhibitor. Anticancer agent with apoptosis inducing with antiangiogenic activity. Antioxidant, vasorelaxant and neuroprotective agent. NF-kappaB activation inhibitor. Inflammasome inhibitor. Potent selective 11beta-HSD1 inhibitor. Improves insulin sensitivity and lipid metabolism. Estrogen receptor ERalpha and ERbeta inhibitor. Inhibits androgen receptor (AR) nuclear translocation and induces AR degradation. VEGFR2, FGFR-1, EGFR, PDGFR-beta and Kit inhibitor. JAK2 inhibitor. Anti-diabetic agent. AMPK activator and PPARgamma agonist. Adipogenesis inhibitor. P2X7 receptor antagonist. Wnt signaling & PI3K/Akt/GSK-3beta pathway modulator.
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
|
|||||||||
List View
