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Ethyl+5-(4-Aminophenyl)oxazole-4-carboxylate
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Ethyl+5-(4-Aminophenyl)oxazole-4-carboxylate
Supplier:
AMBEED, INC
Description:
6-Bromobenzofuran-3(2H)-one, Purity: 97%, CAS Number: 201809-69-0, Appearance: Colorless to Pale-yellow to Yellow-brown to Red Solid or Liquid, Storage: Sealed in dry, 2-8 C, Size: 250mg
Supplier:
VWR International
Description:
From the exclusive family of high-quality, competitively priced BDH Chemicals – High Purity solvents for HPLC applications.
Supplier:
Adipogen
Description:
The BCR-ABL oncogene triggers intracellular signaling, activating multiple transduction cascades, promoting the growth, proliferation and survival of hematopoietic cells. BCR-ABL plays a role in defective DNA repair, alteration of cellular adhesion and inhibition of apoptosis. Degregulated BCR-ABL tyrosine kinase activity is the molecular marker for CML. Inhibiting BCR-ABL tyrosine kinase activity leads to the induction of apoptosis and inhibits cellular proliferation in vitro and there are various BCR-ABL isoforms with differing activity levels as well. Dasatinib (BMS-354825, Sprycel®) is a potent multi-target kinase inhibitor of BCR-ABL. Dasatiinib performs better against ABL kinase than earlier drugs such as imatinib, and Dasatinib also is effective against SRC family of kinases, and other receptor kinases such as EPHA2, PDGFR, and c-Kit. Dasatinib's inhibiting potential against Src family kinase members is greater (IC(50) 0.5nM) than its inhibitory activity against ABL (1nM).
Supplier:
Adipogen
Description:
AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the nanomolar range with over 100-fold selectivity compared with other kinases, apart from ABL and FLT1, which were both moderately sensitive to the compound. In cells, AV-412 inhibited autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, respectively. It also inhibited epidermal growth factor (EGF)-dependent cell proliferation with an IC(50) of 100nM. Moreover, AV-412 abrogated EGFR signaling in the gefitinib-resistant H1975 cell line, which harbors a double mutation of L858R and T790M in EGFR. In animal studies using cancer xenograft models, AV-412 (30mg/kg) demonstrated complete inhibition of tumor growth of the A431 and BT-474 cell lines, which overexpress EGFR and ErbB2, respectively.
Supplier:
Adipogen
Description:
N-Tetradecanoyl-L-homoserine lactone is a small diffusible signaling molecule and is a member of N-acyl-homoserine lactone family. N-acylhomoserine lactones (AHL) are involved in quorum sensing, controlling gene expression, and cellular metabolism. The diverse applications of this kind of molecule include regulation of virulence in general, infection prevention, and formation of biofilms. It appears later than shorter acyl chain AHLs in developing biofilms and, like other long chain AHLs, stimulates bacterial growth. C14-HSL also alters the proteolytic activity and enhances the migration of some strains of Proteus mirabilis. Induces violacein expression in a Chromobacterium violaceum mutant usually not able to produce homoserine lactones.
Catalog Number:
(97064-856)
Supplier:
ALADDIN SCIENTIFIC
Description:
2-(2-Aminothiazol-4-yl)acetic acid ≥98% (by HPLC)
Supplier:
Adipogen
Description:
The lymphocyte-specific kinase (Lck) is a cytoplasmic tyrosine kinase of the Src family expressed in T cells and natural killer (NK) cells. Genetic evidence in both mice and humans demonstrates that Lck kinase activity is critical for signaling mediated by the T cell receptor (TCR), which leads to normal T cell development and activation. Selective inhibition of Lck is expected to offer a new therapy for the treatment of T-cell-mediated autoimmune and inflammatory disease. AMG-47 is one of two optimized chemical compounds that has been shown to be extremely effective in vivo and in vitro in inhibiting Lck as well as a number of other receptor tyrosine kinases. In an anti-CD3/ IL-2 mouse model system AMG-47 has been shown to be effective in inhibiting the Lck mediated anti-inflammatory activity (ED50 11 mg/kg; 630nM) in vivo. In multiple other in vitro assays, AMG-47 exhibits subnanomolar inhibition against Lck, and low (<lt/>10nM) inhibition against other hard to inhibit kinases such as KDR and SRC and MAPK alpha (p38alpha). Moreover at slightly higher doses but well under 10µM, AMG-47 effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2µM.
Supplier:
VWR International
Description:
Ethanol denatured ACS (denatured with 5% isopropanol and 5% methanol), VWR Chemicals BDH®
Catalog Number:
(BDH1160-4LP)
Supplier:
VWR International
Description:
Clear, colorless liquid. Denatured with 3.8–4.5% methanol and 4.0–5.0% 2-propanol. Suitable for cytology and histology.
Catalog Number:
(JT9063-9)
Catalog Number:
(JT9073-5)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Methanol ≥99.9% (by GC), CMOS® for the electronics industry, J.T.Baker®
Catalog Number:
(JT5370-5)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Methanol ≥99.9% VLSI, J.T.Baker®
Catalog Number:
(97065-052)
Catalog Number:
(BDH1162-4LP)
Supplier:
VWR International
Description:
Clear, colorless liquid. Denatured with 3.4–4.0% methanol and 3.6–4.4% 2-propanol. Suitable for cytology and histology.
Catalog Number:
(MK300419)
Supplier:
AVANTOR PERFORMANCE MATERIALS US
Description:
Methanol, anhydrous ≥99.8% (by GC), Macron Fine Chemicals™
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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