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4,4\\\'-sulfinylbis(methoxybenzene)
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4,4\\\'-sulfinylbis(methoxybenzene)
Catalog Number:
(10782-368)
Supplier:
Biosensis
Description:
FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity). FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues: kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In the cerebellum, all the isoforms are abundantly expressed in Purkinje cells.
Catalog Number:
(AAAB21710-18)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Phenol red ACS
Catalog Number:
(TS15143-0250)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Phenol red, pure indicator
Catalog Number:
(AAAA12640-14)
Catalog Number:
(RC5721-4)
Catalog Number:
(101912-200)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 057055-50G , MDL Number: MFCD00008541
Catalog Number:
(101927-950)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 064572-500MG , MDL Number: MFCD00004248
Supplier:
AMBEED, INC
Description:
meso-Tetra(4-carboxyphenyl)porphine 97%
Catalog Number:
(89147-684)
Supplier:
Enzo Life Sciences
Description:
PPARgamma inhibitor
Catalog Number:
(100504-184)
Supplier:
Electron Microscopy Sciences
Description:
A standard indicator for preparing buffers, pH range 6.4 to 8.2.
Catalog Number:
(TCD0803-025G)
Supplier:
TCI America
Description:
CAS Number: 621-01-2
MDL Number: MFCD00008541 Molecular Formula: C15H16N2S Molecular Weight: 256.37 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Melting point (°C): 179
Catalog Number:
(TCP0100-025G)
Supplier:
TCI America
Description:
CAS Number: 143-74-8
MDL Number: MFCD00003552 Molecular Formula: C19H14O5S Molecular Weight: 354.38 Form: Crystal Color: Deep Yellow Red
Catalog Number:
(102989-434)
Supplier:
Adipogen
Description:
Building block for synthesis. Reagent used for electrophilic phenylation, e.g. of malonates and dithiocarboxylates.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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