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4\\\\\\\'-Phenyl-2,2,2-trifluoroacetophenone
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4\\\\\\\'-Phenyl-2,2,2-trifluoroacetophenone
Supplier:
Bachem Americas
Description:
Sequence: Boc-Leu-OSu
Catalog Number:
(10251-592)
Supplier:
Bioss
Description:
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity).
Catalog Number:
(103339-058)
Supplier:
Novus Biologicals
Description:
The DEAF1 Antibody (3F11) from Novus Biologicals is a mouse monoclonal antibody to DEAF1. This antibody reacts with human. The DEAF1 Antibody (3F11) has been validated for the following applications: Western Blot, ELISA.
Catalog Number:
(103339-060)
Supplier:
Novus Biologicals
Description:
The DEAF1 Antibody (3E6) from Novus Biologicals is a mouse monoclonal antibody to DEAF1. This antibody reacts with human. The DEAF1 Antibody (3E6) has been validated for the following applications: Western Blot, ELISA, Immunocytochemistry / Immunofluorescence.
Catalog Number:
(76009-198)
Supplier:
Prosci
Description:
RORA is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene.
Catalog Number:
(103327-600)
Supplier:
Novus Biologicals
Description:
The GSTA1 Antibody (2F7) from Novus Biologicals is a mouse monoclonal antibody to GSTA1. This antibody reacts with human. The GSTA1 Antibody (2F7) has been validated for the following applications: Western Blot, ELISA, Immunohistochemistry-Paraffin.
Catalog Number:
(103331-454)
Supplier:
Novus Biologicals
Description:
The NUBP1 Antibody (2B11) from Novus Biologicals is a mouse monoclonal antibody to NUBP1. This antibody reacts with human. The NUBP1 Antibody (2B11) has been validated for the following applications: Western Blot, ELISA.
Catalog Number:
(103331-486)
Supplier:
Novus Biologicals
Description:
The Necdin Antibody (1B3) from Novus Biologicals is a mouse monoclonal antibody to Necdin. This antibody reacts with human. The Necdin Antibody (1B3) has been validated for the following applications: Western Blot, ELISA, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin, RNA Inhibition.
Catalog Number:
(10814-008)
Supplier:
Prosci
Description:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells.
Catalog Number:
(10070-902)
Supplier:
Prosci
Description:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
Supplier:
Shenandoah Biotechnology
Description:
Growth hormone (GH) is an important mitogenic growth factor that is synthesized, stored, and secreted by somatotropic cells of the anterior pituitary gland. GH stimulates growth, cell reproduction, and cell regeneration. In children, GH deficiencies can cause short stature, growth failure, and delayed sexual maturity. Adult GH deficiency presents with reduced lean body mass, increased adiposity, reduced muscle strength, and ultimately premature mortality. GH replacement therapy is used to treat many growth disorders, including Turner syndrome, chronic renal failure, and Prader–Willi syndrome.
Supplier:
VWR International
Description:
General purpose column, ideal as confrmation column.
Supplier:
VWR International
Description:
General purpose column, ideal as confrmation column.
Catalog Number:
(E-1530.0025BA)
Supplier:
Bachem Americas
Description:
Sequence: Bz-Tyr-OEt
Catalog Number:
(TS32772-1000)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Bis(2-hydroxyethyl)amino tris(hydroxymethyl)methane (BIS-TRIS) 99+% for biochemistry
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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