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2-Chloro-4-cyanobenzoic+acid
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2-Chloro-4-cyanobenzoic+acid
Catalog Number:
(103701-730)
Supplier:
ADVANCED BIOMATRIX, INC. MS
Description:
Advanced BioMatrix offers PhotoCol®, a purified methacrylated Type I bovine collagen kit. PhotoCol® provides native-like 3D collagen gels with the unique attributes to be prepared at various concentrations and crosslinked to provide various gel stiffness.
The PhotoCol® kit consists of purified methacrylated Type I bovine collagen as the core component with other support reagents in the kit. The methacrylated Type I collagen is produced from telo-peptide intact bovine collagen where the collagen has been modified by reacting the free amines, primarily the e-amines groups of the lysine residues as well as the a-amines groups on the N-termini. Approximately 40% of the total lysine residues of the collagen molecule have been methacrylated. The collagen is extracted from bovine hide and contains a high monomer content. The collagen starting material was isolated from a closed herd and purified using controlled manufacturing processes. A bottle of 20 mM acetic acid solution is provided to solubilize the lyophilized methacrylated collagen at concentrations ranging from 3 to 8 mg/ml.The neutralization solution consists of an alkaline 10X phosphate buffered saline (PBS) solution which provides physiological salts and pH in the final mixture.The photoinitiator consists of Irgacure 2959 to be formulated in methanol (methanol not included) which allows UV crosslinking of the collagen at 365 nm. 
Catalog Number:
(10235-858)
Supplier:
Bioss
Description:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
Catalog Number:
(75877-350)
Supplier:
MP Biomedicals
Description:
The total protein is measured using the Biuret procedure, with bovine albumin as a standard. Antibody titer of the IgG fraction is standardized by equivalence-point precipitation. F(ab')2 fragments are tested for purity and specificity at a minimum of 20 mg/mL using immunoelectrophoresis. The product is goat F(ab')2; no trace of albumin, whole molecule IgG or Fc is detected.
The F(ab')2 fragment is prepared from the specific goat IgG fraction by limited digestion with pepsin, and purified by gel filtration or affinity chromatography. The resulting F(ab')2 fragment is dialyzed into 0.02M sodium phosphate, 0.14M sodium chloride, pH 7.3, 0.05% sodium azide, adjusted to standard titer, filtered through a 0.22 μm filter, vialed and lyophilized. Goat F(AB')2 fragment to Human IgM is used as a precipitating antibody. It gives sharp precipitin lines in immunoelectrophoresis and immunodiffusion techniques. This product is suitable for conjugation with enzymes, radiolabels, fluorochromes or other markers, and for attachment to solid supports for use as an immunoadsorbant. This product is suitable for use as a primary reagent in enzyme immunoassays, fluorescein immunoassays and blot, cell or tissue immunostaining. F(ab')2 fragments are recommended for staining of cells or tissues which contain Fc receptors. (Note: Affinity purified antibodies are recommended to avoid non-specific binding from the inherent antibodies of host animals).
Catalog Number:
(RL606-4303)
Supplier:
Rockland Immunochemical
Description:
This product has been assayed against 1.0 µg of Guinea Pig IgG in a standard capture ELISA using ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])
Catalog Number:
(RL604-1303)
Supplier:
Rockland Immunochemical
Description:
This product has been assayed against 1.0 µg of Dog IgG in a standard capture ELISA using ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])
Catalog Number:
(75842-648)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The MF23 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression. Mutations of Foxp3 result in the “scurfy†mice phenotype. It is reported that the MF23 antibody recognizes an epitope between 1-87 amino acids in the N-terminal domain of mouse Foxp3.
Catalog Number:
(75842-074)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The 341 monoclonal antibody specifically reacts with the beta chain of the Rat CD8 molecule. The alpha and beta chains of the CD8 molecule form a heterodimer common on most thymocytes. The CD8 positive T cells of athymic rats and most NK cells express a homodimer composed solely of CD8a. It is reported that macrophages express CD8 alpha and beta chains for signal transduction. CD8 is an antigen co-receptor that interacts with MHC class I molecules on antigen-presenting cells.
Catalog Number:
(75844-392)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
Catalog Number:
(75842-362)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.
Catalog Number:
(75843-752)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.
Catalog Number:
(75844-466)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the α subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.
Catalog Number:
(75843-938)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
Catalog Number:
(75843-940)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
Catalog Number:
(75843-188)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.
Catalog Number:
(75841-682)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The 17A2 monoclonal antibody specifically reacts with the MouseT lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.
Catalog Number:
(75844-362)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The HP-3G10 monoclonal antibody specifically binds to an 80 kDa homodimer type II membrane glycoprotein from the C-type lectin superfamily, known as the human CD161 or NKR-P1A. CD161 is expressed on most natural killer cells, subsets of CD4+ and CD8+ T lymphocytes, γδ TCR T lymphocytes, a subset of CD3+ thymocytes, and especially on CD45RO+ T lymphocytes. Reports indicate that it may serve as a specific receptor for some natural killer cell targets and a possible stimulatory role.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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