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4-(2,4-Difluorobenzoyl)piperidine+hydrochloride
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4-(2,4-Difluorobenzoyl)piperidine+hydrochloride
Catalog Number:
(101803-650)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 013665-500MG , MDL Number: MFCD08447189
Supplier:
Adipogen
Description:
AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519 caused cell cycle arrest followed by apoptosis in human tumor cells and inhibited tumor growth in human tumor xenograft models. Tumor regression was observed following twice daily dosing of AT7519 in the HCT116 and HT29 colon cancer xenograft models. Also it has been shown that the biological effects are linked to inhibition of CDKs in vivo and that AT7519 induces tumor cell apoptosis in these xenograft models. Moreover, AT7519 has an attractive biological profile and is well tolerated and effective making it a more plausible candidate for clinical development than previously available CDK inhibitors. In in vitro kinase assays AT7519 showed nanomolar levels of activity from <lt/>10 to 2400 for cyclins; only one other non-cyclin related kinase was inhibited at levels below 10µM (GSK3beta, 89nM), all others tested had IC(50)'s of greater than 10,000nM.
Catalog Number:
(101803-692)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 013889-500MG , MDL Number: MFCD08447194
Supplier:
THOMAS SCIENTIFIC INC MX
Description:
100 volumes SD Alcohol #1 (100 volumes ethanol, 5 volumes methanol)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Tryptamine hydrochloride 98%
Catalog Number:
(102837-896)
Supplier:
Matrix Scientific
Description:
1,3-Benzoxazol-5-ylacetic acid ≥97%
Supplier:
TCI America
Description:
CAS Number: 503-74-2
MDL Number: MFCD00002726 Molecular Formula: C5H10O2 Molecular Weight: 102.13 Purity/Analysis Method: >99.0% (GC) Form: Clear Liquid Boiling point (°C): 175 Flash Point (°C): 79 Specific Gravity (20/20): 0.93
Catalog Number:
(IC15493310)
Supplier:
MP Biomedicals
Description:
Coomassie Blue R-250 is a triphenylmethane dye used extensively in SDS-PAGE for the analysis of proteins.
Catalog Number:
(101937-150)
Supplier:
Matrix Scientific
Description:
MF=C6H8Cln3O2 MW=189.60 Cas=13924-94-2 5G
Supplier:
AMBEED, INC
Description:
Methyl-3-(thiazol-2-yl)benzoate 95%
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
New fuchsine
Supplier:
Invitrogen
Description:
Thermo Scientific Pierce EDC is a carboxyl- and amine-reactive zero-length crosslinker. EDC reacts with a carboxyl group first and forms an amine-reactive O-acylisourea intermediate that quickly reacts with an amino group to form an amide bond with release of an isourea by-product. The intermediate is unstable in aqueous solutions and so two-step conjugation procedures rely on N-hydroxysuccinimide (NHS) for stabilization. Failure to react with an amine will result in hydrolysis of the intermediate, regeneration of the carboxyl, and release of an N-substituted urea. A side reaction is the formation of an N-acylurea, which is usually restricted to carboxyls located in hydrophobic regions of proteins.
Catalog Number:
(102836-140)
Supplier:
Matrix Scientific
Description:
N-Methyl-N-[(2-methyl-1H-imidazol-4-yl)methyl]amine ≥97%
Catalog Number:
(101935-722)
Supplier:
Matrix Scientific
Description:
Methyl-(2-Methyl-6-Piperidin-3-Yl-Pyrimidin-4-Yl)-Amine Dihydrochloride, MF=C11H20Cl2N4 MW=279.21 250Mg
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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