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H-d-Ser(tBu)-OMe·HCl
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H-d-Ser(tBu)-OMe·HCl
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Hydrogen chloride 4 N in 1,4-dioxane, AcroSeal™
Supplier:
Enzo Life Sciences
Description:
Acid stop solution (1 N HCl) intended for use as an assay stop reagent for colorimetric HRP/TMB reactions.
Supplier:
AMBEED, INC
Description:
4-(Pyrimidin-2-ylmethyl)-7-(4-(trifluoromethoxy)phenyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one hydrochloride 98%
Catalog Number:
(10386-822)
Supplier:
Bioss
Description:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells.
Catalog Number:
(10338-766)
Supplier:
Bioss
Description:
p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins. Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Catalog Number:
(97063-774)
Supplier:
VWR
Description:
A concentrated solution prepared with Biotechnology Grade powder for convenient use in nucleic acid and protein purification procedures.
Catalog Number:
(AAH33474-18)
Supplier:
Thermo Scientific Chemicals
Description:
50g CAS: 6119-47-7, MDL: MFCD00151248
Catalog Number:
(TS40179-5000)
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
Benzamidine hydrochloride 99%
Catalog Number:
(80054-464)
Supplier:
MilliporeSigma
Description:
Blocks glibenclamide-sensitive K+ channels. Inhibits neuronal nitric oxide synthase (IC50=90uM). Also inhibits hepatic drug metabolism by inhibiting the cytochrome P450 system. CAS: 62-68-0. FW: 390. Purity: >98% by TLC. Soluble in water. 1g white solid.
Supplier:
MilliporeSigma
Description:
L-Arginine monohydrochloride, Grade: Ph Eur,BP,JP,USP, Chemical Formula: C6H14N4O2*HCl, CAS: 1119-34-2, Synonyms: A-Amino- delta -guanidino valerianic acid hydrochloride, alpha-Amino-delta-guanidino valerianic acid hydrochloride, Arg, Volume: 1kg
Catalog Number:
(89152-354)
Supplier:
Enzo Life Sciences
Description:
Ca2+ channel inhibitor
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
o-Phenylenediamine dihydrochloride 99+%
Catalog Number:
(103727-808)
Supplier:
HCL Label
Description:
HCL's no food or drink allowed label is made of a durable adhesive vinyl.
Catalog Number:
(103459-120)
Supplier:
HCL Label
Description:
HCL's class 1 laser product label is very durable and a great value.
Supplier:
BeanTown Chemical
Description:
CAS: 50-01-1; EC No: 200-002-3; MDL No: MFCD00013026; RTECS: MF4300000
Crystalline; Molecular Formula: CH5N3·HCl; MW: 95.53
Melting Point: 180-185°
Density (g/mL): 1.344
Hygroscopic
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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