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M\\u00F6dinger+Elektro-Gro\\u00DFhandelshaus
Catalog Number:
(76375-930)
Supplier:
ELECTRON MICROSCOPY SCIENCE
Description:
Geneva pattern, thin tips.
Catalog Number:
(80087-478)
Supplier:
Sartorius
Description:
This pipette stand holds your pipettes in an upright position while not in use to avoid contamination from benches and tables.
Catalog Number:
(101410-780)
Supplier:
Electron Microscopy Sciences
Description:
Aqueous Solutions
Catalog Number:
(101411-026)
Supplier:
Electron Microscopy Sciences
Description:
For staining nuclei
Catalog Number:
(10252-082)
Supplier:
Bioss
Description:
SH3 and multiple ankyrin repeat domains 1-3 (Shank1-3) of the Shank/ProSAP family are molecular scaffolds in the postsynaptic density (PSD). The PSD is an electron-dense structure underneath the postsynaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the presynaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). Shank recruits betaPIX and PAK to spines to regulate postsynaptic structure and interacts with NMDA receptor and metabotropic glutamate receptor complexes. Transcript splice variation in the Shank family influences the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain to ensure normal development.
Catalog Number:
(10251-126)
Supplier:
Bioss
Description:
The ProSAP family of proteins contain many protein-protein interaction domains and serve as scaffolding mediators within the post-synaptic density (PSD) of excitatory brain synapses. The PSD is an electron-dense structure underneath the post-synaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the pre-synaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). ProSAPiP1 (proline rich synapse associated protein interacting protein 1) is a 673 amino acid protein that interacts with the PDZ domain of Shank 3. ProSAPiP1 expression is brain-specific with highest expression within the cerebellum, hippocampus and cerebral cortex.
Catalog Number:
(10251-122)
Supplier:
Bioss
Description:
The ProSAP family of proteins contain many protein-protein interaction domains and serve as scaffolding mediators within the post-synaptic density (PSD) of excitatory brain synapses. The PSD is an electron-dense structure underneath the post-synaptic plasma membrane of excitatory synapses that anchors and clusters glutamate receptors opposite to the pre-synaptic neurotransmitter release site. Shank proteins contain PDZ modular domains that coordinate the synaptic localization of ion channels, receptors, signaling enzymes, and cell adhesion molecules. The PDZ domain mediates protein-protein interactions via the recognition of a conserved sequence motif at the C-terminus of their target protein(s). ProSAPiP1 (proline rich synapse associated protein interacting protein 1) is a 673 amino acid protein that interacts with the PDZ domain of Shank 3. ProSAPiP1 expression is brain-specific with highest expression within the cerebellum, hippocampus and cerebral cortex.
Supplier:
Electron Microscopy Sciences
Description:
Bouin's fixative is used on biopsy specimens of the gastrointestinal tract.
Supplier:
Electron Microscopy Sciences
Description:
Ready-to-use, prefilled with 10% formalin.
Catalog Number:
(102091-216)
Supplier:
Electron Microscopy Sciences
Description:
The Aqua-Hold Pap Pen draws a liquid repellent barrier around a section of tissue. Used like a paint pen, you just draw a well on a slide. The barrier creates the proper surface tension to hold aqueous solutions such as costly antibody and other valuable specimens.
Catalog Number:
(KM402-200406)
Supplier:
KMG
Description:
Acetone can be used for drying laboratory glassware, removing greasy or oily contaminants from work benches, or as a general photoresist stripper or edgebead remover.
Supplier:
Strem Chemicals Inc
Description:
Halides for CVD & ALD, Volatile Precursors for CVD
Catalog Number:
(RL609-303-002)
Supplier:
Rockland Immunochemical
Description:
Secondary Mouse Anti-IgG (H&L) Reacts with Human
Supplier:
Electron Microscopy Sciences
Description:
Kit consists of 500 mL LR Gold Resin, 100g Polyvinylpyrolidone; 50g Benzoyl Peroxide, and 50g Benzil.
Supplier:
Biotium
Description:
Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic Cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, Cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of Cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of Cytochrome c and to induce cell death. The release of Cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a Cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total Cytochrome c which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).
Catalog Number:
(100504-838)
Supplier:
Electron Microscopy Sciences
Description:
This mixture is less viscous than the final embedding mixture of EMbed-812.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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