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cis-Bis(2,2'-bipyridine)dichlororuthenium(II)+hydrate
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cis-Bis(2,2'-bipyridine)dichlororuthenium(II)+hydrate
Catalog Number:
(10235-840)
Supplier:
Bioss
Description:
The human insulin receptor is a heterotetrameric membrane glycoprotein consisting of disulfide linked subunits in a beta-alpha-alpha-beta configuration. The beta subunit (95 kDa) possesses a single transmembrane domain, whereas the alpha subunit (135 kDa) is completely extracellular. The insulin receptor exhibits receptor tyrosine kinase (RTK) activity. RTKs are single pass transmembrane receptors that possess intrinsic cytoplasmic enzymatic activity, catalyzing the transfer of the gamma phosphate of ATP to tyrosine residues in protein substrates. RTKs are essential components of signal transduction pathways that affect cell proliferation, differentiation, migration and metabolism.Included in this large protein family are the insulin receptor and the receptors for growth factors such as epidermal growth factor, fibroblast growth factor and vascular endothelial growth factor. Receptor activation occurs through ligand binding, which facilitates receptor dimerization and autophosphorylation of specific tyrosine residues in the cytoplasmic portion. The interaction of insulin with the alpha subunit of the insulin receptor activates the protein tyrosine kinase of the beta subunit, which then undergoes an autophosphorylation that increases its tyrosine kinase activity. Three adapter proteins, IRS1, IRS2 and Shc, become phosphorylated on tyrosine residues following insulin receptor activation. These three phosphorylated proteins then interact with SH2 domain containing signaling proteins.
Catalog Number:
(10750-480)
Supplier:
Prosci
Description:
ZBED3 Antibody: Axin is a key modulator of the Wnt/beta-catenin pathway and acts as a scaffold protein in phosphorylating and degrading cytoplasmic beta-catenin. ZBED3, a member of the Zinc finger BED-type domain containing superfamily, has been recently identified as an Axin-interacting protein and has been suggested to modulate the Wnt/beta-catenin signaling pathway. RNA interference (RNAi) experiments targeting ZBED3 RNA attenuated Wnt-induced beta-catenin accumulation, lymphoid enhancer binding factor-1-dependent luciferase reporter activity, and Wnt gene expression.
Catalog Number:
(77525-084)
Supplier:
AFG BIOSCIENCE LLC
Description:
Simian IFNb (Interferon Beta) ELISA Kit
Supplier:
CUBE BIOTECH
Description:
Mild, non-ionic detergents such as Dodecylmaltoside are well suited for the solubilization, stabilization, and purification of membrane proteins. For screening of the best-suited detergent for a given application, we offer maltosides with chain lengths from C-9 to C-13.
Catalog Number:
(77694-841)
Supplier:
LGC STANDARDS
Description:
Mycophenolic Acid-d3 beta-D-Glucuronide, TRC, LGC Standards
Catalog Number:
(76118-098)
Supplier:
Bioss
Description:
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Catalog Number:
(77525-828)
Supplier:
AFG BIOSCIENCE LLC
Description:
Rabbit βTG (Thromboglobulin, Beta) ELISA Kit
Supplier:
LGC STANDARDS
Description:
Glycochenodeoxycholic Acid-3-O-Beta-glucuronide Disodium Salt, TRC, LGC Standards
Catalog Number:
(10247-892)
Supplier:
Bioss
Description:
Beta-tectorin is a 329 amino acid secreted protein that contains one zona pellucida (ZP) domain. While it may form homomeric filaments after self-association, Beta-tectorin may also form heteromeric filaments when it associates with ?tectorin. The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia and proteolytically released into the extracellular compartment. Beta-tectorin is one of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
Catalog Number:
(76703-044)
Supplier:
AFG BIOSCIENCE LLC
Description:
Human Integrin Beta-6(ITGB6) ELISA Kit
Catalog Number:
(76714-564)
Supplier:
AFG BIOSCIENCE LLC
Description:
Human Tryptase beta 2 (TPSB2) ELISA Kit
Catalog Number:
(76714-792)
Supplier:
AFG BIOSCIENCE LLC
Description:
Human Integrin Beta-5(ITGB5) ELISA Kit
Catalog Number:
(10103-668)
Supplier:
Prosci
Description:
KIRREL2 is a single-pass type I membrane protein. KIRREL2 protein is a beta-cell-expressed Ig domain protein and may be involved in pancreas development or beta cell function.
Catalog Number:
(89358-118)
Supplier:
Genetex
Description:
T cell receptors (TCR) recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level.
Catalog Number:
(77122-310)
Supplier:
Prosci
Description:
RXR beta Peptide
Catalog Number:
(103617-186)
Supplier:
Sino Biological
Description:
This antibody was obtained from a rabbit immunized with purified, recombinant Human IFN beta (rh IFN beta; Catalog#10704-H02H; NP_002167.1; Met1-Asn187).
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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The original product is no longer available. The replacement shown is available.
This product is no longer available. Alternatives may be available by searching with the VWR Catalog Number listed above. If you need further assistance, please call VWR Customer Service at 1-800-932-5000.
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