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4-(Piperidin-4-yl)benzoic+acid+hydrochloride
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4-(Piperidin-4-yl)benzoic+acid+hydrochloride
Catalog Number:
(BT138620-1G)
Supplier:
BeanTown Chemical
Description:
CAS: 5470-17-7; MDL No: MFCD00233989
UN No: UN2811; Haz Class: 6.1; Packing Group: III
Solid; Molecular Formula: C5H2BrClN2O2; MW: 237.44
Melting Point: 66-70°
Catalog Number:
(10285-190)
Supplier:
Bioss
Description:
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Catalog Number:
(10329-122)
Supplier:
Bioss
Description:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].
Catalog Number:
(RL102-4107)
Supplier:
Rockland Immunochemical
Description:
Secondary Rabbit Anti-IgM mu chain Reacts with Cat (Feline)
Supplier:
BeanTown Chemical
Description:
CAS: 12039-83-7; EC No: 234-904-3; MDL No: MFCD00151541
UN No: UN3178; Haz Class: 4.1; Packing Group: III
-325 Mesh Powder; Linear Formula: TiSi2; MW: 104.05
Melting Point: 1760°
Supplier:
BeanTown Chemical
Description:
CAS: 2437-29-8; EC No: 219-441-7; MDL No: MFCD00011766; RTECS: BQ1190000
UN No: UN2811; Haz Class: 6.1; Packing Group: III
Solid; Molecular Formula: C52H54N4O12; MW: 927.02
Melting Point: 144-150°
Catalog Number:
(J-1120.0050BA)
Supplier:
Bachem Americas
Description:
Z-GPR-MNA, a thrombin substrate which has been modeled after a thrombin cleavage site in human fibrinogen, can be used for a sensitive assay of antithrombin III activity. Z-GPR-MNA is also cleaved by cathepsin K and granzyme A and, according to Valchanov et al., a most efficient substrate for the demonstration of rat mast cell tryptase in histochemistry.
Catalog Number:
(10111-460)
Supplier:
Prosci
Description:
SNAPc is involved in transcription by two types of polymerases; it is required for transcription of both the RNA polymerase II and III small-nuclear RNA genes and binds specifically to the proximal sequence element PSE, a non-TATA-box basal promoter element common to these two types of genes. In addition, SNAPc is composed of at least three TAFs, SNAP43, SNAP45 and SNAP50.
Catalog Number:
(89268-736)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to POLR3F (N-terminal)
Supplier:
Strem Chemicals Inc
Description:
Size: 0.1g.
Catalog Number:
(10100-756)
Supplier:
Prosci
Description:
Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human.
Catalog Number:
(BT225655-1G)
Supplier:
BeanTown Chemical
Description:
CAS: 14099-01-5; EC No: 237-948-1; MDL No: MFCD00013296
UN No: UN3466; Haz Class: 6.1; Packing Group: III
Crystalline; Linear Formula: ReCl(CO)5; MW: 361.71
Air Sensitive, Moisture Sensitive
Supplier:
BeanTown Chemical
Description:
CAS: 133-32-4; EC No: 205-101-5; MDL No: MFCD00005664; RTECS: NL5250000
UN No: UN2811 ; Haz Class: 6.1; Packing Group: III
Crystalline/Powder; Molecular Formula: C12H13NO2; MW: 203.24
Melting Point: 122-125°
Air Sensitive
Supplier:
Honeywell Research Chemicals
Description:
Ethylenediaminetetraacetic acid disodium salt solution , 0.05Â M EDTA-Na2, Grade: Analytical, CAS: 139-33-3, MF: [-CH2N(CH2CO2Na)CH2CO2H]2, Molar mass: 372.24 g/mol, Quality: volumetric, Container Type: Poly bottle, Size: 500ML
Catalog Number:
(75791-432)
Supplier:
Prosci
Description:
Interleukin-22 Receptor Subunit alpha-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. IL22RA2 functions as an IL22 antagonist and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Supplier:
BeanTown Chemical
Description:
CAS: 76469-41-5; EC No: 000-000-0; MDL No: MFCD03001162
UN No: UN1993; Haz Class: 3; Packing Group: III
Liquid; Molecular Formula: C5H2F3N; MW: 133.07
Flash point: 30°C (86°F)
Density (g/mL): 1.400
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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