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Tris(cyclopentadienyl)yttrium(III)
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Tris(cyclopentadienyl)yttrium(III)
Catalog Number:
(10049-564)
Supplier:
Enzo Life Sciences
Description:
Synapsin I, II and III belong to a family of neuron-specific phosphoproteins which maintain a reserve pool of vesicles in the vicinity of the active zone by tethering synaptic vesicles to each other and to an Actin-based cytoskeleton meshwork. They have been shown to regulate neurotransmitter release in mature synapses and to accelerate development of the nervous system.
Supplier:
ACROBIOSYSTEMS INC MS
Description:
Mouse EGF Protein, Fc Tag, ACROBiosystems
Catalog Number:
(75791-424)
Supplier:
Prosci
Description:
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
Catalog Number:
(75790-310)
Supplier:
Prosci
Description:
Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.
Supplier:
BeanTown Chemical
Description:
CAS: 764-13-6; EC No: 212-115-5; MDL No: MFCD00008904
UN No: UN3295; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: (CH3)2C=CHCH=C(CH3)2; Molecular Formula: C8H14; MW: 110.20
Melting Point: 11-14°; Boiling Point: 132-134°; Flash point: 29°C (84°F)
Density (g/mL): 0.773 ; Refractive Index: 1.476
Catalog Number:
(10232-836)
Supplier:
Bioss
Description:
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
Catalog Number:
(10232-842)
Supplier:
Bioss
Description:
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
Supplier:
BeanTown Chemical
Description:
CAS: 617-35-6; EC No: 210-511-2; MDL No: MFCD00009123
UN No: UN3272; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: CH2COCOOCH2CH3; Molecular Formula: C5H8O3; MW: 116.12
Boiling Point: 144°; Flash point: 46°C (115°F)
Density (g/mL): 1.045; Refractive Index: 1.404
Supplier:
BeanTown Chemical
Description:
CAS: 367-57-7; EC No: 206-698-5; MDL No: MFCD00000427
UN No: UN1224; Haz Class: 3; Packing Group: III
Liquid; Linear Formula: CF3COCH2COCH3; Molecular Formula: C5H5F3O2; MW: 154.09
Boiling Point: 105-107°; Flash point: 26°C (79°F)
Density (g/mL): 1.270; Refractive Index: 1.388
Supplier:
BeanTown Chemical
Description:
CAS: 207683-21-4; EC No: 233-051-4; MDL No: MFCD00150188
UN No: UN3288; Haz Class: 6.1; Packing Group: III
Crystalline; Linear Formula: Na2PtCl4·xH2O; MW: 382.88 (anhydrous)
Melting Point: 100°
Supplier:
VWR
Description:
A reversible metalloprotease inhibitor useful for chelating metal ions.
Catalog Number:
(10764-666)
Supplier:
Prosci
Description:
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc gamma I receptor.
Catalog Number:
(10764-662)
Supplier:
Prosci
Description:
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc gamma I receptor.
Catalog Number:
(PI37542)
Supplier:
Invitrogen
Description:
These StartingBlockâ„¢ blocking buffers are PBS and TBS formulations of a proprietary protein that provides exceptional performance and broad compatibility with membrane (Western blot) and 96-well plate (ELISA) assays.
Catalog Number:
(EM1.03000.1000)
Supplier:
DWK Life Sciences (KIMBLE)
Description:
Test tubes made from KG-33 borosilicate glass with a [ST] top and a [ST] glass stopper.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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