You Searched For: DIAGNOSTIC BIOSYSTEMS INC

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 55 kDa protein. Glucose is fundamental to the metabolism of mammalian cells. Several glucose transporter protein (Glut) isoforms have been identified and shown to function in response in insulin and IGF-1 induced signaling. GLUT-1 is detectable in many human tissues including those of the colon, lung, stomach, esophagus and breast. GLUT-1 immunoreactivity in some cancers, including trans-carcinoma of the urinary bladder, has been associated with aggressive behavior.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with α-chains of human IgA. This antibody has been adsorbed to a very high level of specificity.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a glycoprotein of MW 110 kDa, present on the surface of hematopoietic cells i.e. myeloid and lymphoid progenitors. It stains the vascular endothelial cells.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.

Catalog Number: (76633-446)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes heavy chain of human skeletal myosin. It does not stain cardiac or smooth muscle myosin. This antibody stains the fast twitch (type II) isomyosin molecule.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with chains of human IgA. This antibody has been adsorbed to a very high level of specificity.

Supplier: Diagnostic Biosystems

Description: Monoclonal anti-bcl-10 reacts specifically with human bcl-10. The epitope recognized by the antibody resides within amino acids 122-168 of human bcl-10 molecule. Bcl-10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (caspase recruitment domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl-10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl-10 cellular overexpression induces JNK, p38, and NF-kB activation. Deregulation of bcl-10 expression was also demonstrated to be involved in cellular oncogenesis.

Supplier: Diagnostic Biosystems

Description: Negative controls are used to determine the specificity of an antibody. No staining should be observed when the primary antibody is omitted.This product is specifically designed to work with rabbit, mouse and goat antibodies. The Broad Spectrum Negative Control has been titered to work with Polymer-based Secondary Systems in manual and automated IHC platforms.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with cytokeratins of 58, 56, 52, 60, 51, 48 and 68 kDa MW. This antibody is well suited for the staining of a broad spectrum of human keratins.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes most of the acidic (Type I) keratins. It recognizes keratin polypeptides of 50 and 56.5 kDa. In keratinized epidermis, 50 kDa keratin is present in the basal layer, while 56.5 kDa keratin is present in suprabasal layers. This antibody can be used to stain distinct cell layers in an epithelial tissue and various neoplasms of epithelial origin.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with human myeloperoxidase. It stains granules of neutrophils, granulocytes in spleen, bone marrow, tonsil and blood smears.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes insoluble elastin, α-elastin, soluble non-cross linked precursor of elastin (tropoelastin). Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues.

Supplier: Diagnostic Biosystems

Description: This AE1/AE3 antibody cocktail recognizes most of the acidic (Type I) keratins as well as basic (Type II). It recognizes keratin polypeptides of 40, 48, 50, 52, 54, 56.5, 58, 59 and 64 to 67 kDa. In keratinized epidermis, 50 kDa keratin is present in the basal layer, while 56.5 kDa keratin is present in suprabasal layers. 58 kDa keratin is present in the basal and suprabasal layers, while 65 to 67 kDa keratin is present in the cells above the basal layers. This antibody can be used to stain distinct cell layers in an epithelial tissue and various neoplasms of epithelial origin.

Supplier: Diagnostic Biosystems

Description: Steptavidin-conjugted Alkaline Phosphatase. Ready To Use Immunostaining Kit Component

Catalog Number: (76634-530)

Supplier: Diagnostic Biosystems

Description: Podoplanin is a 38 kDa membrane mucoprotein originally detected on the surface of rat podocytes .The antibody against podoplanin (D2-40) reacts to a 40 kDA sialogylcoprotein found on lymphatic endothelium, fetal testis, and on the surface of testicular germ cell tumors. Podoplanin can be used to assist pathologists in identifying lymphatic endothelium to determine lymphatic invasion and also can be used to help differentiate mesothelioma from adenocarcinoma.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 100 kDa glycoprotein expressed by endothelial cells and 130 kDa glycoprotein present in platelets. It stains endothelial cells in normal as well as malignant tissues.