You Searched For: DIAGNOSTIC BIOSYSTEMS INC

Supplier: Diagnostic Biosystems

Description: This antibody recognizes an uncharacterized antigen present in both adults and fetal normal hepatocytes to produce a distinct granular cytoplasmic staining. This antibody stains majority of hepatocellular carcinomas.

Catalog Number: (99990-084)

Supplier: Diagnostic Biosystems

Description: Blocking Buffer, Background Blocker

Catalog Number: (76634-460)

Supplier: Diagnostic Biosystems

Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with the whole H. pylori. The antibody stains the bacteria present on the surface of the epithelium or in the cytoplasm of the epithelial cells. H. pylori is known to cause peptic ulcer and chronic gastritis in humans.

Catalog Number: (76634-854)

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with a 32 kDa protein similar to the CD8 molecule. This antibody stains cytotoxic/suppressor T cells and shows staining patterns similar to clustered CD8 monoclonal antibodies.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with an antigen of 265 to 400 kDa belonging to a heterogeneous group of heavily glycosylated proteins called human milk fat globule proteins. It stains both normal and neoplastic cells. Among normal epithelia, it reacts strongly with mammary epithelium and glandular epithelia but shows a patchy staining with squamous epithelium.

Supplier: Diagnostic Biosystems

Description: PermaBlue Plus/AP is a substrate-chromogen system designed to be used for either IHC or ISH when utilizing alkaline phosphatase

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a cell surface glycoprotein of 80-95 kDa, known as CD44. CD44 is expressed on the surface of lymphocytes, monocytes and granulocytes. This antibody reacts with red cells pretreated with 2-aminoethlyl isothiouronium bromide (AET).

Supplier: Diagnostic Biosystems

Description: Inhibin is a dimeric glycoprotein hormone from the TGF-β family made of α and β subunits. This antibody recognizes the 32kDa α subunit of human inhibin. Inhibin α is expressed in a wide variety of human tissues, such as brain, prostate, adrenal, granulose cells of ovary, sertoli cells of testis and in fetoplacental unit.

Supplier: Diagnostic Biosystems

Description: Complement 4d (C4d) is the most clinically used marker for humoral rejection. It is a degradation product of the activated complement factor C4b. Complement 4d is typically initiated by binding of antibodies to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. Complement 4d is also found in intracytoplasmic vacuoles of endothelial cells. Covalent binding renders C4d a stable molecule that can easily be detected by immunohistochemistry.

Supplier: Diagnostic Biosystems

Description: Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, Uroplakin II/III cocktail is specific for tumors of urothelial origin and, when used in combination with other markers, can aid in the diagnosis of primary and metastatic tumors.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to epithelial membrane antigen (EMA), CA 15-3, or polymorphic epithelial mucin. This antibody stains an underglycosylated MUC1 often present on carcinoma cells.

Catalog Number: (76634-464)

Supplier: Diagnostic Biosystems

Description: The clone F7.2.38 is specific for the non-glycosylated epsilon chain of the human CD3 molecule. Clone F7.2.38 recognizes T cells in the thymus, bone marrow, peripheral lymphoid tissue and blood and is a pan T cell marker. The CD3 molecule consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. The CD3 antigen is first detected in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage.

Catalog Number: (76634-474)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 46 kDa cytokeratin protein designated cytokeratin 17. It reacts with basal cells in complex epithelia and reacts strongly with squamous cell carcinomas.

Catalog Number: (76634-382)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 110 kDa human CD57 myeloid associated glycoprotein. It stains mononuclear cells with natural killer activity, neuroendocrine cells and their tumors.

Supplier: Diagnostic Biosystems

Description: This antibody is specific for α-skeletal muscle actinin and α-cardiac actinin. It stains Z lines and dots in stress fibers of myotubes in skeletal and cardiac muscle but not in non-sarcomeric muscle elements.