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1-(2,5-Difluoro-4-hydroxyphenyl)ethanone
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1-(2,5-Difluoro-4-hydroxyphenyl)ethanone
Supplier:
Matrix Scientific
Description:
MF=C6H4F2O MW=130.09 Cas=2713-33-9 MDL=MFCD00010315 25G
Supplier:
Adipogen
Description:
GSK2126458 is an orally available selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) enzymesand MTOR1/2 complexes. GSK2126458 can inhibit PI3K-alpha (p85alpha/p110alpha) with IC(50) of 0.04nM. GSK2126458 has Ki values in the picomolar range for each of the class I PI3K isoforms and MTOR1/2 complexes. GSK2126458 has potent in vitro and in vivo growth-inhibitory effects on cancer cells. In comparison with other clinical PI3K inhibitors, GSK2126458 is around 100-fold more potent than BEZ235 (6nM). GSK2126458 also a low picomolar inhibitor of the common activating mutants of p110R ( E542K, E545K, and H1047R ) with Ki of 0.008nM, 0.008nM and 0.009nM in human cancer. In mechanistic cellular assays, GSK2126458 caused a significant reduction in the levels of pAKT-S473 with remarkable potency. Consistent with its activity against both PI3K R and mTOR, GSK2126458 also inhibits phosphorylation of AKT-T308 and p70S6K at low nanomolar concentrations. GSK2126458 induces a G1 cell cycle arrest and inhibits cell proliferation in a large panel of cell lines, including T47D and BT474 breast cancer lines.
Supplier:
AMBEED, INC
Description:
2-Bromo-4,6-difluoroanisole 98%
Supplier:
AMBEED, INC
Description:
3',5'-Dimethyl-2'-hydroxyacetophenone, Purity: 98%, CAS Number: 1198-66-9, Appearance: White to Orange to Green powder to crystal, Storage: Inert atmosphere, Room Temperature, Size: 25g
Catalog Number:
(AAH26369-06)
Supplier:
TCI America
Description:
CAS Number: 99-91-2
MDL Number: MFCD00000624 Molecular Formula: C8H7ClO Molecular Weight: 154.59 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Boiling point (°C): 237 Flash Point (°C): 118 Freezing point (°C): 15 Specific Gravity (20/20): 1.19
Catalog Number:
(101781-238)
Supplier:
AMBEED, INC
Description:
1,2-Dibromo-3,5-difluorobenzene 98%
Supplier:
Matrix Scientific
Description:
MF=C7H4F2O MW=142.11 Cas=2646-91-5 MDL=MFCD00010292 100G
Catalog Number:
(TCA1997-25G)
Supplier:
TCI America
Description:
CAS Number: 13031-43-1
MDL Number: MFCD00017229 Molecular Formula: C10H10O3 Molecular Weight: 178.19 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 170 Melting point (°C): 54
Catalog Number:
(AAH26028-MD)
Supplier:
AMBEED, INC
Description:
2',6'-Dichloro-3'-fluoroacetophenone, Purity: 98%, CAS Number: 290835-85-7, Appearance: Solid or liquid, Storage: Sealed in dry, Room Temperature, Size: 25g
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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