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1-(2-Amino-3-methylphenyl)ethanol
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1-(2-Amino-3-methylphenyl)ethanol
Supplier:
Adipogen
Description:
Fluorescent dye. Fluorophore standard that is widely used in enzyme assay systems. Precursor for a variety of R110-based enzyme substrates for flow cytometric measurements. Used as a calibration standard for R110-based enzyme substrates. Compared to AMC and AFC enzyme substrates, fluorogenic R110 substrates are generally more sensitive, giving longer absorption and fluorescence wavelength than AMC and AFC substrates. Spectral data: lambdaex 498nm| lambdaem 520nm in methanol.
Supplier:
Adipogen
Description:
Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs).
Supplier:
BeanTown Chemical
Description:
CAS: 111-42-2; EC No: 203-868-0; MDL No: MFCD00002843; RTECS: KL2975000
Liquid/Low Melting Solid; Linear Formula: HN(CH2CH2OH)2; Molecular Formula: C4H11NO2; MW: 105.14
Melting Point: 28°; Boiling Point: 217°/150 mmHg; Flash point: 138°C (280°F)
Density (g/mL): 1.097; Refractive Index: 1.477
Hygroscopic
Supplier:
Adipogen
Description:
Verapamil hydrochloride is an alpha-adrenergic receptor (alpha-AR) antagonist and calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Verapamil is an antiarrhythmic agent and vasodilator known to reduce the renal clearance of digoxin and induce apoptosis in primary and metastatic colon adenocarcinoma human cell lines in vitro. It has been observed that verapamil can induce currents by itself, presumably by acting on the potassium and chloride leakage. Verapamil has also been used as an inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein). Verapamil is a substrate of CYP3A4 and CYP2C6. It is also used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Recent research has shown verapamil to be an effective treatment for diabetes in animal models. Verapamil helps treat diabetes by limiting TXNIP expression.
Supplier:
Adipogen
Description:
pan-Akt inhibitor targeting Akt1, 2, 3 with IC50 values of 2, 13 and 9 nM, respectively. Inhibits AMPK, DAPK3, PAK4, 5 and 6, as well as members of the AGC kinase family including PKA, PrkX and PKC isoforms (IC50 <lt/> 100 nM). Occupies the ATP binding pocket of the kinase domain and competes with ATP. Anti-cancer compound both in vitro and in vivo. Blocks the phosphorylation of downstream targets of ATK in a dose-dependent manner, which leads to antiproliferative and apoptotic effects in tumor cell lines. Induces hyperglycemia related to peripheral insulin resistance, increased gluconeogenesis, and/or hepatic glycogenolysis.
Supplier:
BeanTown Chemical
Description:
CAS: 102-71-6; EC No: 203-049-8; MDL No: MFCD00002855; RTECS: KL9275000
Liquid; Linear Formula: (HOCH2CH2)3N; Molecular Formula: C6H15NO3; MW: 149.19
Melting Point: 19-21°; Boiling Point: 190-193°/5 mmHg; Flash point: 185°C (365°F)
Density (g/mL): 1.124; Refractive Index: 1.485
Air Sensitive, Hygroscopic
Catalog Number:
(102991-280)
Supplier:
Adipogen
Description:
CD14/TLR4 antagonist. Inhibitor of sterile inflammation. Synthetic TLR4/CD14 ligand with TLR4 modulating activities in vitro, and conferring protection against TLR4/CD14-mediated tissue damage and inflammation in vivo. Useful to explore CD14- dependent and TLR4-independent pathways and TLR4 activation by endogenous ligands (e.g. hyaluronic acid oligosaccharides, oxLDL, HMGB1) in sterile inflammation. Shown to inhibit neuropathic pain, secondary necrosis of acute drug-induced liver failure and vascular inflammation, and abdominal aortic aneurysm by blocking non-hematopoietic TLR4 signaling. Useful tool, where inhibition of sterile (auto-) inflammation is desired, without compromising TLR4’s key role in the defense of pathogens.
Supplier:
MP Biomedicals
Description:
Soluble in water (50 mg/l- clear, colorless to slight yellowish solution) or methanol; less soluble in ethanol; practically insoluble in ether and ethyl acetate.
Supplier:
AMBEED, INC
Description:
4,4',4''-Tris[phenyl(m-tolyl)amino]triphenylamine 95%
Catalog Number:
(AA42773-AE)
Supplier:
Thermo Scientific Chemicals
Description:
sodium salt, 0.1% w/v Aqueous Solution,UN1170,Liquid,DANGER: FLAMMABLE, causes CNS effects, irritates skin & eyes,100ml.FLAMMABLE LIQUID,
Catalog Number:
(10075-446)
Supplier:
Prosci
Description:
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gamma;s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKCepsilon regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)
Supplier:
MP Biomedicals
Description:
Protein purification reagent Triethanolamine acts as an organic additive in the grinding of cement clinker and as a complexing agent for aluminum ions in aqueous solutions.
It is used as an emulsifier and a surfactant. It finds application in common products like dishwashing liquids, general cleaners, hand cleaners, shaving cream, metalworking fluids, liquid laundry detergents, paints and printing inks. It is used for the neutralization of fatty acids and adjusting buffer pH as well as utilized to dissolve oils. It acts as an effective complexing agent in electroless plating. Further, it is used in hair care products like hair dyes and wave sets.
Supplier:
VWR International
Description:
Ethanol denatured ACS (denatured with 5% isopropanol and 5% methanol), VWR Chemicals BDH®
Supplier:
MP Biomedicals
Description:
Trypan blue is a blue acid dye with a strong affinity for cellulose containing substrates such as cotton; less affinity for proteinaceous materials.
Supplier:
BeanTown Chemical
Description:
CAS: 3618-43-7; EC No: 222-805-8; MDL No: MFCD00044293
Powder; Molecular Formula: C31H28N2Na4O13S; MW: 760.59
Melting Point: 195° (decomposes)
Supplier:
Adipogen
Description:
Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Blocks class I, class II and class III PI3Ks, including some downstream targets. Blocks class I PI3K persistently and class III PI3K transiently. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition. Anticancer compound. Neuroprotective. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
This product is marked as restricted and can only be purchased by approved Shipping Accounts. If you need further assistance, email VWR Regulatory Department at Regulatory_Affairs@vwr.com
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