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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

GSK690693 ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste
Danger

AG-CR1-3628-M005 AG-CR1-3628-M025
102987-440EA 131.54 USD InStock
102987-440 102987-442
GSK690693 ≥95%
GSK690693
pan-Akt inhibitor targeting Akt1, 2, 3 with IC50 values of 2, 13 and 9 nM, respectively. Inhibits AMPK, DAPK3, PAK4, 5 and 6, as well as members of the AGC kinase family including PKA, PrkX and PKC isoforms (IC50 100 nM). Occupies the ATP binding pocket of the kinase domain and competes with ATP. Anti-cancer compound both in vitro and in vivo. Blocks the phosphorylation of downstream targets of ATK in a dose-dependent manner, which leads to antiproliferative and apoptotic effects in tumor cell lines. Induces hyperglycemia related to peripheral insulin resistance, increased gluconeogenesis, and/or hepatic glycogenolysis.


Formula: C₂₁H₂₇N₇O₃
Storage Temperature: Freezer
 MDL Number: MFCD14105605
CAS Number: 937174-76-0
UN: 2811
ADR: 6.1,III
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Specification Test Results
Purity 95%
Appearance/Color Off-white to pale yellow solid.
Solubility Soluble in DMSO. Slightly soluble (1mg/ml) in ethanol.

 

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