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2-Bromo-6-(methoxycarbonyl)benzoic+acid
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2-Bromo-6-(methoxycarbonyl)benzoic+acid
Supplier:
Adipogen
Description:
The kinases called p38 MAP kinases (MAPKs) are intracellular, soluble serine-threonine kinases which belong to a large family of proteins that include the extracellular regulated kinases (ERKs) and c-Jun N-terminal kinases (JNKs). So far four p38 isoforms have been identified, namely p38alpha, p38beta, p38gamma and p38delta, a.k.a. p38-alpha (MAPK14), -beta (MAPK11), -gamma (MAPK12 / ERK6), and -delta (MAPK13 / SAPK4). The ubiquitously expressed s p38alpha has been the most extensively studied and is believed to be the most physiologically relevant in the regulation of the inflammatory response. The role of the three other isoforms is not currently well understood, however their primary sites of expression are known. Similar to p38alpha, p38beta is also ubiquitously expressed, while p38gamma is expressed predominately in skeletal muscle and p38delta is expressed primarily in the lung, kidney, testis, small intestine and pancreas. The small molecule inhibitor VX-702 is a potent p38 kinase family inhibitor that has been studied for its effects on inflammation and the inflammatory response. VX-702 dose-dependently inhibited the production o IL-6, IL-1beta and TNFalpha (IC(50) = 59, 122 and 99ng/ml, respectively), and in anti-platelet aggregation assays, pre-incubation of platelets with VX-702 (1µM)completely or partially inhibited platelet agonist induced p38 activation (IC(50) = 4 to 20nM). More recently VX-702 has been studied as a potential treatment for rheumatoid arthritis (RA). VX-702 appears to be most effective against MAPK14, followed by MAPK11 and the remaining members of the family, however exact in vitro IC(50) values have not been published. However a large amount of data is available for in vitro growth inhibition assays where VX-702 exhibits poptent activity, having low IC(50) values beginning at ~16nM and ending at < 400µM for the numerous cell lines tested.
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
4'-Iodoacetophenone 98%
Supplier:
Matrix Scientific
Description:
MF=C6H6Bio2 MW=247.83 Cas=5122-99-6 MDL=MFCD01319014 1G
Supplier:
THERMO FISHER SCIENTIFIC CHEMICALS
Description:
4'-Iodoacetanilide 97%
Catalog Number:
(77692-887)
Supplier:
LGC STANDARDS
Description:
(2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic Acid (3,3',5'-Triiodo-L-Thyronine), Mikromol, LGC Standards
Supplier:
APOLLO SCIENTIFIC
Description:
3-Iodobenzyl alcohol, Technical Grade
Catalog Number:
(101787-866)
Supplier:
Matrix Scientific
Description:
MF=C7H7Is MW=250.10 Cas=33775-94-9 MDL=MFCD00051611 25G
Supplier:
AOB CHEM USA
Description:
2-Bromo-6-iodoanisole ≥95%
Supplier:
Matrix Scientific
Description:
MF=C11H15I MW=274.15 Cas=85017-60-3 MDL=MFCD00079767 1G
Catalog Number:
(89157-116)
Supplier:
Enzo Life Sciences
Description:
Cannabinoid receptor ligand.
Supplier:
Matrix Scientific
Description:
MF=C8H7Io MW=246.05 Cas=14452-30-3 MDL=MFCD00060283 25G
Supplier:
AMBEED, INC
Description:
2-((2-Chloro-4-iodophenyl)amino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide, Purity: 98%, CAS Number: 212631-79-3, Appearance: Form: Crystal - Powder / Colour: White - Very pale yellow, Storage: Keep in dark place, Inert atmosphere, Store in freezer, under -20C, Size: 1MG
Supplier:
AMBEED, INC
Description:
4-Iodobenzylamine hydrochloride 97%
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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