1-(2-Aminophenyl)piperazine
Catalog Number:
(101834-802)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 032988-500MG , MDL Number: MFCD01764472
Catalog Number:
(TCS0580-25G)
Supplier:
TCI America
Description:
CAS Number: 599-79-1
MDL Number: MFCD00057363 Molecular Formula: C18H14N4O5S Molecular Weight: 398.39 Purity/Analysis Method: >95.0% (HPLC,T) Form: Crystal Color: Yellow Melting point (°C): 246
Catalog Number:
(101843-974)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 037698-500MG , MDL Number: MFCD12027168
Supplier:
AOB CHEM USA
Description:
4-(1-Piperidinyl)benzeneboronic acid pinacol ester ≥97%
Supplier:
AMBEED, INC
Description:
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl piperidine-1-carboxylate, Purity: 96%, CAS Number: 913836-28-9, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 250MG
Catalog Number:
(101840-294)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 035901-500MG , MDL Number: MFCD09701634
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 048167-500MG , MDL Number: MFCD01899691
Catalog Number:
(101934-524)
Supplier:
Matrix Scientific
Description:
MF=C10H13N3O2 MW=207.23 250Mg
Supplier:
AMBEED, INC
Description:
1-Boc-4-piperidineacetic acid 97%
Catalog Number:
(101844-312)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 037853-500MG , MDL Number: MFCD12027241
Catalog Number:
(101847-034)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 039208-500MG , MDL Number: MFCD12027711
Catalog Number:
(101846-964)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 039172-500MG , MDL Number: MFCD12027676
Catalog Number:
(101847-036)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 039209-500MG , MDL Number: MFCD12027712
Supplier:
Adipogen
Description:
AT7519 is a potent inhibitor of several CDK family members. AT7519 showed potent antiproliferative activity (40-940nM) in a panel of human tumor cell lines, and the mechanism of action was shown here to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT7519 caused cell cycle arrest followed by apoptosis in human tumor cells and inhibited tumor growth in human tumor xenograft models. Tumor regression was observed following twice daily dosing of AT7519 in the HCT116 and HT29 colon cancer xenograft models. Also it has been shown that the biological effects are linked to inhibition of CDKs in vivo and that AT7519 induces tumor cell apoptosis in these xenograft models. Moreover, AT7519 has an attractive biological profile and is well tolerated and effective making it a more plausible candidate for clinical development than previously available CDK inhibitors. In in vitro kinase assays AT7519 showed nanomolar levels of activity from <lt/>10 to 2400 for cyclins; only one other non-cyclin related kinase was inhibited at levels below 10µM (GSK3beta, 89nM), all others tested had IC(50)'s of greater than 10,000nM.
Supplier:
AMBEED, INC
Description:
1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine, Purity: 97%, CAS Number: 852227-97-5, Appearance: Solid, Storage: Inert atmosphere, Room Temperature, Size: 1g
Catalog Number:
(101849-782)
Supplier:
Matrix Scientific
Description:
Matrix Scientific Part Number: 040575-500MG , MDL Number: MFCD12028283
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