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Description:
Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50=17uM). Acts as peripheral vasodilator. Inhibitor of lysosomal sphingomyelinase. CAS: 69-09-0. FW: 355.3. Purity: >=99% by titration. Soluble in methanol, ethanol and water. 500mg white solid.
Description:
Ethyl 3-amino-3-methylbutanoate hydrochloride, Purity: 95%, CAS number: 85532-40-7, Appearance: White to pale-yellow powder or crystals, Storage: Keep in dark place, Inert atmosphere, Room temperature, Size: 250MG
Description:
alpha1-Adrenergic receptor (alpha-AR) antagonist. Prototypical calcium channel protein inhibitor that blocks the L-type Ca2+ channels in smooth and cardiac muscle cells. Vasodilator known to reduce the renal clearance of digoxin and used to control hypertension, angina, cardiac arrhythmia and vascular headaches. Apoptosis inducer in primary and metastatic colon adenocarcinoma human cell lines in vitro. Inhibitor of drug efflux pump proteins such as Mdr (P-glycoprotein) which are often over-expressed in certain tumor cell lines. Substrate of CYP3A4 and CYP2C6. Used in fluorescent cell sorting for DNA content, as it blocks efflux of a variety of DNA-binding fluorophores such as Hoechst 33342. Anti-diabetic in animal models by limiting TXNIP expression.