4026850.0005
4026850.0025
N-1505.0005BAEA
1143.76
USD
InStock
N-1505.0005BA
N-1505.0025BA
Dec-RVKR-CMK
Dec-RVKR-CMK
Sequence: Decanoyl-Arg-Val-Lys-Arg-chloromethylketone
Synonym(s): Furin Inhibitor I#Dec-RVKR-CMK#Furin Convertase Inhibitor (Chloromethylketone)
Dec-RVKR-CMK binds to the catalytic site of furin and therefore acts as a potent inhibitor of cleavage and fusion activity of viral glycoproteins, as well as virus replication. Furthermore it was demonstrated that this compound decreased the production of β-amyloid-induced active matrix metalloproteinase 2 in U87 cells. Apart from furin, N-1505 also inhibited the proprotein convertases PC7/LPC, PACE4, and PC6 (W.Garten, personal communication).