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H-1152 dihydrochloride ≥98% (by HPLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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270-423-M001 270-423-M005 270-423-M025
89147-860EA 97.01 USD InStock
89147-860 89147-862 89147-864
H-1152 dihydrochloride ≥98% (by HPLC)
H-1152 dihydrochloride
A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (Ki=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain.

  • ROCK inhibitor

White to off-white solid.

Soluble in water.


Formula: C₁₆H₂₁N₃O₂S·2HCl
MW: 319.4 · 73.0 g/mol
Storage Temperature: Freezer
 CAS Number: 45146-2-58-1
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