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8-(4-Chlorophenylthio)-2'-O-methyladenosine-3’,5’-cyclic monophosphate sodium salt ≥98%

Supplier: SAFE AND SURE NEDERLAND B.V.
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480-093-M001 480-093-M005
89151-588EA 277.95 USD InStock
89151-588 89151-590
8-(4-Chlorophenylthio)-2'-O-methyladenosine-3’,5’-cyclic monophosphate sodium salt ≥98%
8-(4-Chlorophenylthio)-2'-O-methyladenosine-3’,5’-cyclic monophosphate sodium salt
Specific, potent and membrane permeant activator of the Epac cAMP receptor.

  • Formulation: White to off-white crystalline powder.

Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither in vitro nor in vivo and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator.

Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.

Hygroscopic and soluble in water, aqueous buffers, DMSO, dimethyl formamide or methanol.

Synonym: 8-CPT-2'-O-Me-cAMP.Na


Formula: C₁₇H₁₆ClN₅O₆PS·Na
MW: 507.8 g/mol
Storage Temperature: Freezer
 CAS Number: 510774-50-2
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Specification Test Results
Purity (HPLC) ≥98%
Identity Determined by ESI-MS and UV
Purity detail Product is not sterile

 

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