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Icilin ≥97% (by TLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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BML-CM126-0010 BML-CM126-0050
89156-976EA 123.17 USD InStock
89156-976 89156-978
Icilin ≥97% (by TLC)
Icilin
TRPM8 activator.

  • Formulation: Light yellow to orange solid.

Cooling agent. Strongly activates TRPM8 (IC₅₀ = 0.2 µM), cold menthol receptor 1 (CMR1, IC₅₀ = 0.36 µM), a nonselective, cold-activated cation channel and TRPA1 (at 10- to 100-fold higher concentration). Induces currents in TRPM8 expressing HEK 293 cells (EC₅₀ = 0.36 mM) more potently than menthol or low temperatures. Activates TRPM8 with variable latency, followed by extensive desensitisation provided calcium is present. The effects of icilin can be impacted by both pH and cytosolic calcium levels.

Soluble in DMSO (50 mg/mL).

Synonym: AG 3-5, 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone.


Formula: C₁₆H₁₃N₃O₄
MW: 311.297 g/mol
 MDL Number: MFCD01689072
CAS Number: 36945-98-9
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Specification Test Results
Purity ≥97% (TLC)

 

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