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Geldanamycin ≥95% (by HPLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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BML-EI280-0001 BML-EI280-0005
89157-956EA 163.5 USD InStock
89157-956 89157-958
Geldanamycin ≥95% (by HPLC)
Geldanamycin
Potent antitumor antibiotic

  • Yellow solid

Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Capable of destabilizing several oncogene and proto-oncogene products. Potent inhibitor of the nuclear hormone receptor family. Protects against alpha-synuclein toxicity to dopaminergic neurons in Drosophila. Destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells. Hsp90 inhibitors geldanamycin or 17-DMAG reduces the uptake of Chaperone Mediated Autophagy (CMA) substrates by isolated lysosomes. 10-fold more potent than herbimycin A.

Inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src, and yes.

Soluble in DMSO (10 mg/mL); insoluble in water

Envase: Shipping temperature: Ambient


Formula: C₂₉H₄₀N₂O₉
Storage Temperature: Freezer
 MDL Number: MFCD00274570
CAS Number: 30562-34-6
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