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Ko143 ≥96% (by HPLC)

Supplier: SAFE AND SURE NEDERLAND B.V.
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BML-EI396-0005 BML-EI396-0025
89158-270EA 206.01 USD InStock
89158-270 89158-272
Ko143 ≥96% (by HPLC)
Ko143
Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.

  • BCRP inhibitor

White solid.

Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).


Formula: C₂₆H₃₅N₃O₅
MW: 469.6 g/mol
Storage Temperature: Freezer
 CAS Number: 461054-93-3
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