BML-PG050-0001
BML-PG050-0005
89161-528EA
164.59
USD
InStock
89161-528
89161-530
15-Deoxy-δ-12,14-prostaglandin J2 ≥97% (by TLC)
15-Deoxy-delta-12,14-prostaglandin J2
Prostaglandin D2 derived nuclear peroxisome proliferator-activated receptor γ (PPARγ) ligand. Induces apoptosis in a number of cell types including human lung cancer cells, synoviocytes and macrophages. Promotes differentiation of fibroblasts to adipocytes. Antiinflammatory activity. Inhibits angiogenesis. Prevents TNFα induced leptin increase in mice. TRPA1 agonist. Serious doubts as to the biological relevance of this prostaglandin have been raised. Endogenous levels seem to be too low to have any effect as a PPARγ ligand.
Neat oil. Vials may appear empty because the oil tends to coat the inside of the vial.
Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).