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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Streptomycin sulphate, 766 IU/mg (Dry basis)

Supplier: E. Becker & Co. GmbH

0210055605 0210055650 0210055680 0210055691 0210055625
IC10055605EA 28.84 USD InStock
IC10055605 IC10055650 IC10055680 IC10055691 IC0210055625
Streptomycin sulphate, 766 IU/mg (Dry basis)
Streptomycin sulphate
Streptomycin Sulfate is an aminoglucoside antibiotic in which streptidine is linked glycosidically to the disaccharide streptobiosamine.

  • Presentation: White Powder
  • Half life: in plasma, about 2-4 hours
  • Sulfated ash: 0.3%
  • Loss on drying: 4.33%

Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition. It inhibits gram-negative and gram-positive bacteria.

Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation.
Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.

Typically used at a concentration of 50-100 mg/liter

Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition

Soluble in 4% aq soln-Clear, Colorless Solution


Formula: C₂₁H₃₉N₇O₁₂·1.5H₂SO₄
MW: 1457.4 g/mol
Melting Pt: 250
Storage Temperature: Refrigerator
 MDL Number: MFCD00037023
CAS Number: 3810-74-0
Merck Index: 12,08983
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=028b4342e8065607f96642a0a7777d5269772370&vid=028b4342e8065607f96642a0a7777d5269772370&prid=web&clid=SAPDAM
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Specification Test Results
Identity Test Passes
Activity 766 IU/mg (Dry basis)
FTIR Conforms to Standard
Loss on Drying 4.33%
Solubility (4% aq soln) Clear, Colorless Solution
pH 5.8
Streptomycin B <3.0%
Sulfated Ash 0.3%
Sulfate 19.4%
Colorimetric Test 98.2%
Bacterial Endotoxins <0.25 IU/mg
Abnormal Toxicity 1mg/0.5ml
Sterility Passes
Sodium Metabisulfate 0.012%

 

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