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Actinomycin D (from Streptomyces parvulus) ~98%, crystalline powder

Supplier: E. Becker & Co. GmbH
Danger

0210465801 0210465805 0210465825 0210465850 0210465810 0210465880
IC10465801EA 71.92 USD InStock
IC10465801 IC10465805 IC10465825 IC10465850 76102-590 76102-592
Actinomycin D (from Streptomyces parvulus) ~98%, crystalline powder
Actinomycin D
Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.

  • Presentation: Red Crystalline Powder
  • Soluble in methanol (10 mg/mL - clear, orange solution), soluble in DMSO (50 mg/ mL-clear, orange solution), ethanol, chloroform, benzene, ethyl acetate, propylene glycol, chloroform, acetone, water + glycol mixtures.

Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells, and as an antibiotic in treatment of various malignant neoplasms, including Wilm′s tumour and the sarcomas.

Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.

Red crystalline

Soluble in methanol (10 mg/mL - clear, orange solution), soluble in DMSO (50 mg/ mL-clear, orange solution), ethanol, chloroform, benzene, ethyl acetate, propylene glycol, chloroform, acetone, water + glycol mixtures.

Precaución: Protect from light


Formula: C₆₂H₈₆N₁₂O₁₆
MW: 1255.5 g/mol
Melting Pt: 251…253 °C (lit.)
Storage Temperature: Refrigerator
 MDL Number: MFCD00005033
CAS Number: 50-76-0
UN: 3462
ADR: 6.1 II
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