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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Nisin

Supplier: E. Becker & Co. GmbH

0215583905 0215583925
IC15583905EA 238.17 USD InStock
IC15583905 IC15583925
Nisin
Nisin
Nisin is a polypeptide (34 residues) antibiotic structurally similar to subtilin but containing no tryptophan; a member of the lantibiotic family. Reduces the thermal resistance of bacterial spores in milk-based beverages.The C-terminus of nisin is responsible for the initial interaction of nisin, binding to the target membrane. Active against Gram-positive bacteria at the cytoplasmic membrane.

Antibiotic with bactericidal action. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria (requires chelator such as EDTA).

Soluble in dilute acids such as 0.02 N HCl (118 mg/mL). Any undissolved material is the dairy solids and should not be considered a problem. Stable to boiling in acid solutions.

Nisin is a polypeptide (34 residues) antibiotic structurally similar to subtilin but containing no tryptophan; a member of the lantibiotic family. Reduces the thermal resistance of bacterial spores in milk-based beverages.The C-terminus of nisin is responsible for the initial interaction of nisin, binding to the target membrane. Active against Gram-positive bacteria at the cytoplasmic membrane.


Formula: C₁₄₃H₂₃₀N₄₂O₃₇S₇
 MDL Number: MFCD00131724
CAS Number: 1414-45-5
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=4e67aca2ac5b8ce32bcf086ab349dfcb13e0fd68&vid=4e67aca2ac5b8ce32bcf086ab349dfcb13e0fd68&prid=web&clid=SAPDAM
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Specification Test Results
Synonyms Ambicin N
Concentration Nisin content: 2.5% .Remainder is NaCl and milk solids (denatured).
Form Tan Powder
Storage Store at Room Temperature (15-30 °C).
pH 3.31 (10% aq suspension) (Lit.)

 

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