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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Gentamicin sulphate USP

Supplier: E. Becker & Co. GmbH

02190057.2 0219005701 0219005705 0219005710 0219005725
IC190057.2EA 83.07 USD InStock
IC190057.2 IC19005701 IC19005705 IC19005710 IC19005725
Gentamicin sulphate USP
Gentamicin sulphate
Gentamicin sulfate is an aminoglycoside antibiotic complex produced by fermentation of Micromonospora purpurea or M

  • USP Grade
  • Presentation: White Powder
  • H2O: soluble 50 mg/mL
  • Loss on drying: ≤18.0 %
  • Optical rotation: +107° to +121° (10 mg/mL, water)
  • pH: 3.5 - 5.5 (1 in 25, in water)

Gentamicin sulfate is used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It is used to treat many types of bacterial infections, particularly those caused by Gram-negative organisms.

Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface. Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria.

echinospora. It is a mixture of 3 major components designated as C1, C1a, and C2. Gentamicin is used as the sulfate salt. Each component consists of five basic nitrogens and requires five equivalents of sulfuric acid per mole of gentamicin base.

White

Soluble in Water (50 mg/mL)


Melting Pt: 218…237 °C
Storage Temperature: Refrigerator
 MDL Number: MFCD00270181
CAS Number: 1405-41-0
Merck Index: 13,04403
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=0974207b836b70c181b6bd777d295eb8b293ec7a&vid=0974207b836b70c181b6bd777d295eb8b293ec7a&prid=web&clid=SAPDAM
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Specification Test Results
Identity Test A Passes
Identity Test B Passes
Potency (dry basis) ≥590 μg/mg
Optical Rotation (10 mg/ml, water) +107° to +121°
3.5-5.5
Loss on Drying ≤18.0%
Residue on Ignition ≤1.0%
Limit of Methanol ≤1.0%
Content of Gentamicins C1 = 25 - 50%
C1a = 10 - 35%
C2 + C2a = 25 - 55%

 

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