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Muscimol, powder

Supplier: E. Becker & Co. GmbH

0219533605 0219533610 0219533625
IC19533605EA 169.25 USD InStock
IC19533605 IC19533610 IC19533625
Muscimol, powder
Muscimol
Muscimol is a structural analog of γ-amino butyric acid. It functions as a GABA-agonist: a positive analog of the natural transmitter, which can activate GABA receptors in the brain. Muscimol is an isoxazole derivative occurring naturally in the mushroom Amanita muscaria.

Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.

Soluble in water (10 mg/mL); soluble in 1 N Sodium hydroxide, ethanol, or methanol.

GABAA receptor agonist.


Formula: C₄H₆N₂O₂
 MDL Number: MFCD00057894
CAS Number: 2763-96-4
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=138818f91bab881766c9e567fa7c2c3ba43046e5&vid=138818f91bab881766c9e567fa7c2c3ba43046e5&prid=web&clid=SAPDAM
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