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Verapamil hydrochloride, powder

Supplier: E. Becker & Co. GmbH

0219554501 0219554505 0219554510
IC19554501EA 134.68 USD InStock
IC19554501 IC19554505 IC19554510
Verapamil hydrochloride, powder
Verapamil hydrochloride
(±)-Verapamil Hydrochloride is a α1-antagonist and calcium channel modulator.

(±)-Verapamil hydrochloride is a calcium channel (L-type) modulator, adrenoceptor antagonist, anti-arrhythmic, cardiac depressant, and coronary vasodilator. It is also a calcium channel-blocker. It acts by inhibiting the slow channel entry of calcium into the cell. It acts by plugging up the channels and limiting the entry of calcium into both smooth muscle cells of arteriolar walls and the ardiac muscle cells at higher doses.

Soluble in water (7 g/100 mL); sparingly soluble in chloroform; soluble in ethanol (26 mg/mL), isopropanol, acetone, ethyl acetate; freely soluble in methanol (> 100 mg/mL), DMF (> 100 mg/mL); practically insoluble in ether.

Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.


Formula: C₂₇H₃₈N₂O₄
 MDL Number: MFCD00055208
CAS Number: 152-11-4
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Specification Test Results
Form White Powder
Storage Store at Room Temperature (15-30 °C).
Extinction Coefficient EmM = 16.1 (232 nm in ethanol); 6.1 (280 nm in ethanol)(Lit.)
pka 8.6 (Lit.)

 

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