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Poly-D-lysine hydrobromide, white powder

Supplier: E. Becker & Co. GmbH

0215017510 0215017525 0215017550 0215017580
IC15017510EA 61.61 USD InStock
IC15017510 IC15017525 IC15017550 IC15017580
Poly-D-lysine hydrobromide, white powder
Poly-D-lysine hydrobromide
Poly-lysine is a polycation which binds to DNA, red cell membrane and any negatively charged protein. When adsorbed to the culture surface, poly-lysine increases the number of positively charged sites available for cell binding. A compromise between the easier to use lower molecular weight products and the extremely viscous higher molecular weights would be the products in the range of 70,000-150,000.
It is typically used as a coating substrate for culture dishes, slides, etc. It enhances electrostatic interaction between negatively charged ions of the cell membrane and the culture surface. Both the D- and L- form of the poly-lysine can be used as a coating substrate since poly-lysine is a nonspecific attachment factor for cells; however, certain cells can digest poly-lysine. In this case, poly-D-lysine should be used as the attachment factor so that the cells are not disrupted by excessive uptake of L-lysine.
Other uses for poly-lysine have been reported as well:
• Conjugation to methotrexate for increased drug transport.
• Microencapsulation of islets.
• Use in simple reproducible procedure for chromosomal preparations from a variety of tissues.
• Immobilation of living cells in biocompatible semipermeable microcapsules.
• In the preparation of polycationic beads.
• Conjugation to albumin and horseradish peroxidase to enhance cellular uptake.
Poly-D-lysine hydrobromide is a synthetic amino acid that enhances cell adhesion to solid substrates. It has additionally been shown to eliminate prion proteins from infected cells.

  • Presentation: White Powder
  • Solubility: 50 mg/mL, H20
  • Storage temperature: -20°C

Poly-lysine with molecular weight 30,000 is useful in promoting cell adhesion to solid substrates.

Poly-D-lysine hydrobromide is a synthetic amino acid that enhances cell adhesion to solid substrates. It has additionally been shown to eliminate prion proteins from infected cells.


Formula: C₆H₁₅BrN₂O₂
MW: 227.102 g/mol
Storage Temperature: Freezer
 CAS Number: 27964-99-4
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Specification Test Results
Identity Test Passes
Avg. Molecular Weight 70,000-150,000

 

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