AF-300-05-5UG
AF-300-05-25UG
AF-300-05-100UG
AF-300-05-250UG
AF-300-05-500UG
AF-300-05-1MG
10778-588EA
185.39
USD
InStock
10778-588
10778-590
10778-592
10778-594
10778-596
10778-598
Human Recombinant LIF (from E. coli)
Proteins and Peptides
LIF is a pleiotrophic factor produced by multiple cell types, including T cells, myelomonocytic lineages, fibroblasts, liver, heart and melanoma. LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. Recombinant Human LIF is a 19.6 kDa protein containing 180 amino acids residues, including three disulfide bonds. Manufactured using all Animal-Free reagents.
SPLPITPVNA TCAIRHPCHN NLMNQIRSQL AQLNGSANAL FILYYTAQGE PFPNNLDKLC GPNVTDFPPF HANGTEKAKL VELYRIVVYL GTSLGNITRD QKILNPSALS LHSKLNATAD ILRGLLSNVL CRLCSKYHVG HVDVTYGPDT SGKDVFQKKK LGCQLLGKYK QIIAVLAQAF
Verified by N-terminal and Mass Spectrometry analyses (when applicable).
Información para pedidos: For research use only. Not for use in diagnostic or therapeutic procedures.