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Dithiothreitol (DTT, Cleland's reagent) ≥99% for molecular biology

Supplier: E. Becker & Co. GmbH

02194821.2 0219482101 0219482105 0219482110 0219482150
IC02194821.2EA 38.33 USD InStock
IC02194821.2 IC0219482101 IC0219482105 IC0219482110 IC0219482150
Dithiothreitol (DTT, Cleland's reagent) ≥99% for molecular biology
Dithiothreitol (DTT, Cleland's reagent)
DL-Dithiothreitol is a Clelands reagent; Protective agent for sulfhydryl groups (-SH). Quantitatively reduces disulfides (-S-S- to -SH). In this reaction the DTT is oxidized to the cyclic disulfide which ensures the reduction of other disulfides in solution. Disulfide reduction occurs quickly at pH 8.

  • Storage temperature: +4 °C

DL-Dithiothreitol is used for stabilizing sulfhydryl containing enzymes. It is effective in sample buffers for reducing protein disulfide bonds prior to SDS-PAGE. DTT can also be used for reducing the disulfide bridge of the cross-linker N,N'-bis(acryloyl)cystamine to break apart the matrix of a polyacrylamide gel.


Formula: C₄H₁₀O₂S₂
MW: 154.25 g/mol
Melting Pt: 40…50 °C
Flash Pt: >110 °C (lit.)
 MDL Number: MFCD00004877
CAS Number: 3483-12-3
EINECS: 248-531-9
https://qa.digitalassets.avantorsciences.com/adaptivemedia/rendition?id=5022472c3f3baef75a703791c548fc6504df810f&vid=0c72cc68bbc36ab17baa927731844d74085edbf9&prid=web&clid=SAPDAM
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Specification Test Results
Physical Appearance White Powder
Half Life 0.1 M KPO4 buffer (Half Life in hours):- pH 6.5 at 20 °C: 40, pH 7.5 at 20 °C: 10, pH 8.5 at 20 °C: 1.4, pH 8.5 at 0 °C: 11, pH 8.5 at 40 °C: 0.2, pH 8.5 at 20 °C with addition of 0.1 mM Cu2+: 0.6, pH 8.5 at 20 °C with addition of 1.0 mM EDTA: 4
pH (0.1 M in H2O, 25 °C): 4.0 to 6.0 (Lit.)
Solubility Soluble in water (50 mg/mL - clear and colorless solution); soluble in ethanol, acetone, ethylate, chloroform and ether.

 

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