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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Tozasertib ≥95%

Supplier: Van Der Voort Lucht en Milieu Amste
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SYN-1092-M001 SYN-1092-M005 SYN-1092-M010 SYN-1092-M050
102991-980EA 74.77 USD InStock
102991-980 102991-982 102991-984 102991-986
Tozasertib ≥95%
Tozasertib
Tozasertib, or VX-680, is a potent and selective inhibitor of Aurora kinases, particularly Aurora A and B. In vitro, VX-680 blocks cell cycle progression and induces apoptosis in a wide range of human tumor types at low IC(50) values (i.e. 3.38nM for human BE-13 cells, and 14.34nM for NTERA cells). Moreover, VX680, also has very potent Ki values, with inhibition constants (Ki) of 0.6, 18, and 46nM for Aurora A, B, and C, respectively. VX-680 is also effective in vivo, being used in a Caki-1 xenograft model, VX-680 demonstrated a 75.7% (P < 0.001) decrease in Caki-1 xeno-graft tumor volume with no apparent alternation in animal body weight, peripheral blood counts, or other biological parameters.

In mammals, three Aurora kinases, Aurora A, Aurora B, and Aurora C, are expressed. Aurora C expression is mainly restricted to testis, where it functions during meiosis, whereas Aurora A and B play key functions regulating mitosis. Aurora A is localized to the centrosome and spindle poles, where it drives centrosome maturation, separation, and bipolar spindle assembly. Aurora B is the central component of the chromosomal passenger complex (CPC) that also contains the inner centromere protein (INCENP), borealin, and survivin. These non-enzymatic components of the CPC play a key role in regulating kinase activity and localization. Over-expression of Aurora kinases can be oncogeneic and they have thus long been targets for cancer thearpy.


Formula: C₂₃H₂₈N₈OS
MW: 464.59 g/mol
Storage Temperature: Freezer
 MDL Number: MFCD10565966
CAS Number: 639089-54-6
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Specification Test Results
Purity 95%
Appearance/Color Solid.
Solubility Soluble in DMSO or ethanol.

 

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