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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

Ascomycin ≥98%, high purity

Supplier: Van Der Voort Lucht en Milieu Amste
Warning

AG-CN2-0420-M001 AG-CN2-0420-M005 AG-CN2-0420-M025
102988-212EA 41.54 USD InStock
102988-212 102988-214 102988-216
Ascomycin ≥98%, high purity
Ascomycin
Macrolide antibiotic

Source/Host: Isolated from Streptomyces sp.
Purity: >98%
Appearance/Color: White to off-white solid.
Solubility: Soluble in DMSO or ethanol.

Ethyl analog of FK506. Strong immunosuppressant. Binds to the FK-506-binding protein FKBP12. This complex inhibits calcineurin (protein phosphatase 2B (PP2B)). Suppresses the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in T lymphocytes and preferentially inhibits the activation of mast cells. Anti-inflammatory. Used for topical treatment of inflammatory skin diseases. Potently inhibits anti-IgE-induced histamine and cytokine release and reduces IgE-dependent p38 MAPK activation in human basophils. Inhibits basophil degranulation at the initial phase of allergic skin reactions. Antifungal. Antimalaria compound. Anticonvulsant (antiepileptic).


Formula: C₄₃H₆₉NO₁₂
Storage Temperature: Freezer
 MDL Number: MFCD06198665
CAS Number: 104987-12-4
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