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Update to Avantor’s response to the coronavirus (COVID-19) pandemic

AdipoRon hydrochloride hydrate ≥98% (by HPLC, NMR)

Supplier: Van Der Voort Lucht en Milieu Amste

AG-CR1-0156-M010 AG-CR1-0156-M050
102988-552EA 96.92 USD InStock
102988-552 102988-554
AdipoRon hydrochloride hydrate ≥98% (by HPLC, NMR)
AdipoRon hydrochloride hydrate
Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.


Formula: C₂₇H₂₈N₂O₃·HCl·H₂O
MW: 483 g/mol
Storage Temperature: Freezer
 CAS Number: 924416-43-3
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Specification Test Results
Purity
Appearance/Color White solid
Solubility Highly soluble in DMSO. Soluble in 100% ethanol or methanol. Slightly soluble in water (1mg/ml).

 

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